About this trial
The Myelex study is a fundamental research study that aims to better understand how the brain functions and develops. The objective of this study is to better understand the role of myelin, a sheath that surrounds nerve fibers and determines the speed of information propagation in the brain, in cognitive functioning during development in adolescents and young adults. investigator use Magnetic Resonance Imaging (MRI) because this method allows us to study the anatomy and functioning of the brain in a non-invasive (no injection) and painless manner. investigator focus on cognitive control, a set of cognitive functions in the prefrontal cortex, at the front of the brain, that enable the use of the best strategies on a case-by-case basis to solve problems effectively. These functions are closely associated with academic and professional success and develop late, continuing until early adulthood. The goal of this project is simple: to measure the myelin of nerve fibers using MRI and to evaluate the link with the development of cognitive control. Each participant will undergo an MRI examination and cognitive assessments. The study takes place at the Clinical Research Center of GHU Paris and lasts a total of 3.5 hours, including reception, setup, MRI recording, and the completion of a series of cognitive tasks.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male or female; Subject aged 10 to 25 years; Right-handed preference; Subject, or legal representative, who has given consent to participate; Native language: French; Subject affiliated with a social security system; Having signed their consent to participate (and their legal representative if applicable), subjects and parents have read the information letter and given their free and informed consent. In cases where only one parent gives consent (for minors), this must be justified (such as no contact with the other parent for over a year).
Disqualifiers
Not corresponding to the targeted age range;
Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);
Subject with chronic alcohol or drug use;
Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);
Trial population
Healthy adolescent and adult volunteers aged 10 to 25 years with no contraindications for an MRI examination.
Trial design
Cohort
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Myelin
Myelin Levels : Regional variations of Fractional Anisotropy (FA)
Secondary outcomes
Working Memory
Spatial Span from CANTAB \- Units on a Scale
Inhibitory skills
Stop Signal Task from CANTAB and CHEXI, TEXI and ADEXI self-questionnaires \- Units on a Scale
Planning skills
One Touch Stockings of Cambridge - Units on a Scale
Decision-making and risk-taking
Cambridge Gambling Task from CANTAB - Units on a Scale
Sponsors and contacts
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