The objective of this research is to investigate the clinical outcomes of modified surgical techniques such as omitting the cervical linea alba suture in transthoracic endoscopic thyroidectomy. Furthermore, the study requires the collection of normal thyroid tissues, benign and malignant thyroid tumors, and lymph nodes to further clarify the mechanisms associated with the initiation, progression, metastasis, and recurrence of thyroid cancer.
Perform transthoracic endoscopic thyroidectomy via breast approach;
Postoperative pathology confirms benign or malignant thyroid tumors;
Preoperative thyroid ultrasound or cervical CT suggests no extrathyroidal invasion or distant metastasis of the tumor;
No contraindications for general anesthesia;
Underwent transthoracic endoscopic thyroidectomy;
Postoperative pathology confirmed as benign or malignant thyroid tumors;
Preoperative thyroid ultrasound or neck CT suggested no extraglandular invasion or distant metastasis of the tumor;
No contraindications to general anesthesia;
Parallel
Suturing the cervical linea alba during endoscopic thyroid surgery.
Procedure/SurgerySuturing the cervical linea alba during endoscopic thyroid surgery.
Performing transcriptome sequencing
GeneticPerforming transcriptome sequencing
6
Treatment groupsSee each treatment group below.
Postoperative neck edema Incidence rate
Postoperative neck edema Incidence rate
Postoperative short-term pain
Record the patient's perception of wound pain on postoperative days 1, 3, and 5 using the Numerical Rating Scale (NRS), which ranges from 0 (no pain) to 10 (worst pain), for quantification.
Thyroid Papillary carcinoma tissue mRNA expression profile
After extracting total RNA from tissue, it is purified and a cDNA library is constructed. Following library quality control, sequencing is conducted on the Illumina NovaSeq 6000 platform using the PE150 mode to obtain tissue mRNA expression data.
Thyroid papillary carcinoma metastatic lymph node mRNA expression profile
After extracting total RNA from tissue, it is purified and a cDNA library is constructed. Following library quality control, sequencing is conducted on the Illumina NovaSeq 6000 platform using the PE150 mode to obtain tissue mRNA expression data.
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