Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-75
SponsorRutgers, The State University of New Jersey

About this trial

Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk. Executive Control is a relevant cognitive target since it declines with aging and is critical for multi-tasking in daily life. The proposed research investigates whether playing a web-based cognitive complex game (the Breakfast Game) impacts cognitive performance in cognitively healthy older adults. To be enrolled in the study, participants will be asked to undergo a cognitive sassessment, health questionnires, and a blood exam. The intervention consist in one educational session on healthy aging, and 10 one-hour cognitive training sessions 2-3 times a week over one month. Participants will be asked to repeat the cognitive assessment within 1-2 weeks after the intervention, and after three months.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 60-75

Adequate English proficiency

Attend 2 in-person assessments

Attend a blood test

Disqualifiers

Low test scores (below 26 on the Montreal Cognitive Assessment)

Known history of cognitive impairment, dementia, stroke, seizure disorder, or other neuropsychiatric condition judged to impact cognitive performance.

Taking medications known to influence cognitive performance.

Sensory (e.g. visual, auditory) or physical (e.g. severe arthritic, orthopedic, neurologic) impairment incompatible with use of a standard computer workstation.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Web-based Cognitive Training (with strategy)

    Behavioral

    Participants will learn to play a complex online game using specific guidance or strategy.

  • Web-based Cognitive Training (without strategy)

    Behavioral

    Participants will learn to play a complex online game without specific guidance or strategy.

Treatment groups

130 Participants
are divided into 3 treatment groups
Group A: Strategy TrainingExperimental treatment 1 intervention
Group B: Regular TrainingActive comparator 1 intervention
Group C: Passive ControlNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Changes in the Breakfast Game scores

Change in the total game performance based on specific scores (number of tables and cooking scores). Higher scores represent better game outcomes.

Time frame
Training session 1, week 1; training 10, approximately 4 weeks.
2

Transfer to complex executive/attention control measure (Proximal outcome).

Alphanumeric Task score.

Time frame
At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th)

Secondary outcomes

1

Transfer to executive functions composite measure (Proximal outcome)

Average z-score computed with tests involving working memory, divided attention, and inhibitory control (Letter-Number, UFOV and Stroop)

Time frame
At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th)
2

Transfer to Everyday Cognition Scale (ECOG) (Distal outcome)

Scores on a scale that measures cognitive difficulties in everyday life. A higher score indicates higher levels of cognitive difficulties or change.

Time frame
At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th)
3

Transfer to Mindful Attention Awareness Scale (MAAS) (Distal outcome)

Scores on a scale that measures attention awareness. A higher score indicates higher levels of attention awareness.

Time frame
At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th)
4

Transfer to Self Efficacy for Cognitive Everyday Tasks (Distal outcome)

Scores on a scale that measures self-efficacy. A higher score indicates higher levels of self-efficacy.

Time frame
At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Rutgers, The State University of New Jersey

Lead sponsor

National Institute on Aging (NIA)

Collaborator