Acute uncomplicated diverticulitis is often treated with antibiotics, although current evidence shows that antibiotics are not always necessary. This study will evaluate whether a more standardized approach to treatment can reduce unnecessary antibiotic use without increasing the risk of treatment failure.
The study will compare patients treated before and after the new treatment approach is introduced in participating Swiss hospitals. Information on treatment, hospital admissions, complications and recurrence of diverticulitis will be collected. Patients will be followed for up to 24 months.
Age 18 years or older
CT-confirmirmed acute uncomplicated diverticulitis of the left colon
Ability to provide informed consent for participants in the prospective phase
Complicated acute diverticulitis, defined as diverticulitis with abscess, perforation (free air), fistula, or distant free fluid
Diverticulitis of the right or transverse colon
No possibility of completing the 90-day follow-up
Inability to provide informed consent for the prospective phase
Parallel
standardized treatment algorithm
Other interventionA standardized treatment approach based on clinical findings, laboratory results, comorbidities, immunosuppression status, and CT findings is introduced to support treatment decisions in patients with acute uncomplicated diverticulitis. Depending on these factors, patients may be managed with or without antibiotics.
Treatment failure
Treatment failure is defined as a composite outcome including progression to complicated diverticulitis requiring percutaneous abscess drainage or surgery, delayed initiation of antibiotics after initial management without antibiotics, or unplanned hospital admission following initial outpatient treatment.
Antibiotic use
Proportion of participants receiving antibiotics
Adherence to the standardized treatment approach
Proportion of participants whose management is consistent with the standardized treatment approach.
Outpatient versus inpatient management
Proportion of participants initially managed as outpatients versus inpatients.
Hospital admission
Proportion of participants readmitted to hospital.
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
