Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBaptist Health South Florida
About this trial
To collect and preserve glioblastoma tissue during standard of care tumor resection surgery and blood for future molecular and genetic testing. Tissue for research will be collected from three different regions within the same tumor to study how these regions differ in their structure, DNA, and RNA and also to compare the data obtained from this testing to imaging data found in the medical record. The goal of this study is to help us better understand what the glioblastoma tumor tissue looks like and how it functions. This understanding can lead to new therapies for the treatment of glioblastoma in the future.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Have the appearance of high-grade glioma on magnetic resonance (MR) imaging if allowed to consent and will undergo the procedure if the frozen is consistent with glioblastoma or gliosarcoma OR Patients with a history of histologically confirmed diagnosis of World Health Organization Grade glioblastoma or gliosarcoma that are undergoing repeat resection of a recurrent tumor as identified on preoperative MR imaging
Aged ≥ 18 years old
Contrast-enhancing tumor volume of at least 10 cc on the preoperative, volumetric MRI within 1 month prior to surgery
Provision of signed and dated informed consent form by participant or legally authorized representative (LAR), if applicable
Disqualifiers
None
Trial population
Adults with GBM or gliosarcoma undergoing standard of care tumor resection surgery.
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Specimen Collection
Procedure/SurgeryCollect and preserve glioblastoma tissue for exploratory analyses to generate hypotheses for future studies.
Treatment groups
120 Participants
are divided into 1 treatment groupGroup A: Glioblastoma1 intervention
Trial outcomes
Primary outcomes
1
Number of glioblastoma (GBM) samples for analysis
Total number of GBM samples collected and preserved for analysis
Time frame
2 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Baptist Health South Florida
Lead sponsor
Miami Cancer Institute
Collaborator
Nico Corporation
Collaborator
Source ClinicalTrials.gov