In-depth Characterization of Circulating and Infiltrating Immune Subsets and Tumor Cells in Cancer Patients

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssistance Publique Hopitaux De Marseille

About this trial

The aim of this study is to describe the tumor microenvironment of solid tumors and to understand the changes induced by anti-cancer treatments, particularly those developed by Innate Pharma. Innate Pharma is a biotechnology company which discovers and develops therapeutic antibodies that exploit the innate immune system to improve cancer treatment. Thanks to this study, it will be possible to correlate clinical and immunological characteristics with the patient\'s clinical features. The analyses generated will contribute to the design and improvement of innovative therapeutic antibodies acting on the immune system

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

18 years of age or older

Histologic, cytologic or imaging confirmation of a malignancy in accordance with targeted indications

Written informed consent signed from subject prior to performing any protocol-related procedures

Disqualifiers

Use of any investigational agent within 14 days prior first visit;

Patient under guardianship/trusteeship or legally incapacitated person;

Patient unable to understand read and/or sign an informed consent;

Uncooperative or potentially non-compliant for the study or study procedures patient, or with foreseeable regular follow-up difficulties;

Trial population

Patient from hospitals in Assistance Public Hopitaux de Marseille : Nord, Conception and Timone

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

  • blood collection

    Procedure/Surgery

    Blood sampling is performed during Scrrening / visit 1 for patients enrolled in cohort 1, cohort 2 and cohort 3

  • tissue specimen collection

    Procedure/Surgery

    In Cohort 1- patients with solid tumor undergoing surgery, fresh tissue specimen is collected during surgery

Treatment groups

640 Participants
are divided into 3 treatment groups
Group A: Cohort 1 - Patients with solid tumor undergoing surgery2 interventions
Group B: Cohort 2 - Patients with solid tumor with anti-PD1/PD-L1 treatment and no surgery1 intervention
Group C: Cohort 3 - Patients with hematological malignancies1 intervention

Trial outcomes

Primary outcomes

1

Identification of circulating and infiltrating tumor cells .

Caracterization of tumor cells immuno-phenotyping and gene signature.

Time frame
From screening to end of study at 8 weeks

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: