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In-Hospital Detection of Elevated Blood Pressure

ConditionsHypertensionBlood Pressure, High
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAnnina Vischer

About this trial

The goal of this clinical trial is to analyse the prevalence of new or uncontrolled arterial hypertension (AHT) after hospital discharge of medical in-patients with elevated blood pressure (BP) values during hospitalisation.

The main questions it aims to answer are:

* Do elevated BP values during hospitalisation correspond to new or uncontrolled AHT after hospital discharge? * Is it safe to postpone adaption of antihypertensive treatment until after proper evaluation of AHT after hospital discharge?

Participants will either be treated according to their physicians' decision or antihypertensive treatment adaptions will be postponed until after hospital discharge.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patient hospitalized on the internal medicine ward for non-cardiovascular causes, i.e. patients hospitalized for conditions, which are not acutely worsened by uncontrolled AHT

Asymptomatic elevated BP values (defined as 140-180 mmHg systolic and/or 90-110 mmHg diastolic) on at least 2 occasions

Ability to understand study procedures and to provide written informed consent

Disqualifiers

Cerebrovascular events

Acute coronary syndrome

Acute or decompensated heart failure

Any condition preventing ABPM

Trial design

Design model

Parallel

Treatments tested in this trial

  • Postponement of antihypertensive treatment

    Other intervention

    Hypertensive blood pressure values in medical in-patients will not be treated during hospitalisation until confirmed by ABPM 4 weeks after hospital discharge

Treatment groups

800 Participants
are divided into 2 treatment groups
Group A: Usual practice armNo intervention 0 interventions
Group B: Postponement of treatment armOther 1 intervention

Trial outcomes

Primary outcomes

1

Prevalence of persisting new or uncontrolled arterial hypertension

Elevated blood pressure values in ambulatory blood pressure monitoring

Time frame
4 weeks after hospital discharge
2

Prevalence of a combined hypertensive complication endpoint

Consisting of intracerebral bleeding, ischemic stroke, myocardial infarction, cardiovascular death or cardiovascular re-hospitalization

Time frame
Until 4 weeks after hospital discharge
3

Prevalence of a combined hypotensive complication endpoint

Consisting of falls, acute kidney injury, electrolyte disturbances, re-hospitalizations due to hypotension, or BP values on ABPM below the lower treatment limit

Time frame
Until 4 weeks after hospital discharge

Secondary outcomes

1

Clinic blood pressure measurement in mmHg

Documented in the patient documentation

Time frame
At baseline
2

Research blood pressure measurement in mmHg

Standardized blood pressure measurement taken by research staff

Time frame
At baseline
3

Prevalence of previously unknown arterial hypertension

No previously documented diagnosis of arterial hypertension and no antihypertensive treatment

Time frame
At baseline
4

Prevalence of female gender

As reported by participant

Time frame
At baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Annina Vischer

Lead sponsor

University Hospital, Basel, Switzerland

Sponsor institution

Source ClinicalTrials.gov
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