About this trial
Acute pancreatitis (AP) is a common medical condition characterized by inflammation of the pancreas, affecting a significant portion of the population. With approximately one-third of patients experiencing notable morbidity due to local or systemic complications, the severity of the disease is underscored by the presence of acute peripancreatic fluid collections, acute necrotic collections, pseudocysts, and walled-off necrosis1. Notably, vascular complications, such as splanchnic vein thrombosis, further contribute to the increased morbidity and mortality associated with acute pancreatitis2. Splanchnic vein thrombosis encompasses thromboses in the splenic (SpVT), portal (PVT), and superior mesenteric veins (SMVT), either individually or in combination3. These complications are often incidentally discovered during imaging procedures conducted to assess potential complications4. Despite most cases being asymptomatic, fatal complications, including bowel ischemia, liver failure, portal hypertension, and life-threatening bleeding, have been documented, with the risk of splanchnic vein thrombosis escalating with the severity of pancreatitis
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients aged between 18-85 years of age.
Diagnosis of AP as per international consensus criteria.
Disqualifiers
Chronic pancreatitis.
Established malignancy.
Cirrhosis of liver or established portal hypertension.
Pregnancy.
Trial population
All in-patients with acute pancreatitis, getting admitted from emergency or OPD will be enrolled. Only when a study subject has given informed consent, clinical data will be recorded
Trial design
Other
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Primary outcome
Detection of thrombus in splenic, superior mesenteric or portal vein.
Secondary outcomes
Secondary Outcome
Correlation of splanchnic venous thrombosis with severity of acute pancreatitis.
Secondary Outcome
Incidence of infected pancreatic necrosis/ peri-pancreatic fluid collections in patients with acute pancreatitis having SVT.
Secondary Outcome
Effect of drainage of peripancreatic fluid collections/ necrotic collections on status of thrombosis.
Secondary Outcome
Vessel recanalization on follow-up at 6 months
Sponsors and contacts
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