Incidence of Splanchnic Venous Thrombosis in Acute Pancreatitis and it's Correlation With Severity of Pancreatitis

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorAsian Institute of Gastroenterology, India

About this trial

Acute pancreatitis (AP) is a common medical condition characterized by inflammation of the pancreas, affecting a significant portion of the population. With approximately one-third of patients experiencing notable morbidity due to local or systemic complications, the severity of the disease is underscored by the presence of acute peripancreatic fluid collections, acute necrotic collections, pseudocysts, and walled-off necrosis1. Notably, vascular complications, such as splanchnic vein thrombosis, further contribute to the increased morbidity and mortality associated with acute pancreatitis2. Splanchnic vein thrombosis encompasses thromboses in the splenic (SpVT), portal (PVT), and superior mesenteric veins (SMVT), either individually or in combination3. These complications are often incidentally discovered during imaging procedures conducted to assess potential complications4. Despite most cases being asymptomatic, fatal complications, including bowel ischemia, liver failure, portal hypertension, and life-threatening bleeding, have been documented, with the risk of splanchnic vein thrombosis escalating with the severity of pancreatitis

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged between 18-85 years of age.

Diagnosis of AP as per international consensus criteria.

Disqualifiers

Chronic pancreatitis.

Established malignancy.

Cirrhosis of liver or established portal hypertension.

Pregnancy.

Trial population

All in-patients with acute pancreatitis, getting admitted from emergency or OPD will be enrolled. Only when a study subject has given informed consent, clinical data will be recorded

Trial design

Design model

Other

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Primary outcome

Detection of thrombus in splenic, superior mesenteric or portal vein.

Time frame
1 year

Secondary outcomes

1

Secondary Outcome

Correlation of splanchnic venous thrombosis with severity of acute pancreatitis.

Time frame
1 year
2

Secondary Outcome

Incidence of infected pancreatic necrosis/ peri-pancreatic fluid collections in patients with acute pancreatitis having SVT.

Time frame
1 year
3

Secondary Outcome

Effect of drainage of peripancreatic fluid collections/ necrotic collections on status of thrombosis.

Time frame
1 year
4

Secondary Outcome

Vessel recanalization on follow-up at 6 months

Time frame
6 months

Other outcomes

Sponsors and contacts

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