Health TrialsbyHealthPanel

Indicators Affecting PVT Recanalization

ConditionsPortal Vein ThrombosisCirrhosisPortal Hypertension Related to CirrhosisPortal Hypertension, Noncirrhotic
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorShanghai Zhongshan Hospital

About this trial

This is a retrospective-prospective study conducted at Zhongshan Hospital, Fudan University, to explore portal vein thrombosis (PVT) in patients with cirrhosis and gastroesophageal varices (GEV). It aimed to provide insights into the diagnosis, follow-up, and factors influencing PVT recanalization, to help patients, families, and healthcare providers understand the disease and related clinical management.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

diagnosed as cirrhosis and confirmed gastroesophageal varices by endoscopy;

all patients were diagnosed as PVT by CTA at admission.

Disqualifiers

patients with hepatocellular carcinoma;

patients with extrahepatic malignancies;

history of liver transplantation or TIPS;

lack of information regarding anticoagulation therapy；

Trial population

This study enrolled adult patients with cirrhosis and confirmed gastroesophageal varices who presented to Zhongshan Hospital, Fudan University, and were diagnosed with portal vein thrombosis (PVT)upon admission.

Trial design

Design model

Cohort

Time perspective

Other

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

PVT recanalization at 1 year

Time frame
From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 1 year, death, or the last follow-up, whichever came first

Secondary outcomes

1

Occurrence of all-cause death (competing event)

Time frame
From the date of admission confirmation of PVT to the occurrence of death, or the last follow-up, whichever came first
2

PVT recanalization at 5 years

Time frame
From the first abdominal imaging assessment after admission, until the occurrence of PVT recanalization at 5 year, death, or the last follow-up, whichever came first
3

Occurrence of non-improved PVT

defined as unchanged thrombus size, \<50% thrombus reduction, or thrombus extension to new venous segments

Time frame
From the date of admission confirmation of PVT to the last radiological follow-up at 1 year, or death, whichever came first

Other outcomes

Sponsors and contacts

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Shanghai Zhongshan Hospital

Lead sponsor

Source ClinicalTrials.gov
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