About this trial
Electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are two evidence-based treatments for major depressive disorder. Both work by stimulating the brain (a process known as neuromodulation), but they differ markedly in invasiveness. ECT requires a general anaesthetic, whereas TMS is delivered while a person is awake and alert and they can go home immediately afterwards. TMS has been proposed as an alternative to ECT for some people. However, TMS is not as effective as ECT in all cases, is generally slower acting, and remains less widely available.
In Nottingham and Liverpool, there are a small number of individuals who have experienced both ECT and TMS across different episodes of depression. Whilst previous studies have explored experiences of ECT and TMS separately, often using relatively superficial methods, none have examined the perspectives of people who have received both treatments. This study addresses that gap through an in-depth exploration of their experiences.
The investigators will use a narrative inquiry approach that encourages participants to tell the story of their experiences of ECT and TMS in their own words. Eligible participants will be adults who have previously received both treatments for depression. Participation involves four sessions: a structured discussion to map the timeline of their depression and treatments, two in-depth open-ended interview sessions (narrative inquiry), and a follow-up discussion about the researchers' reconstruction of their story. Recruitment will take place through services in Nottingham and Liverpool.
This study will help to understand how patients relate to, and make sense of, ECT and TMS, which contextual factors shape their experiences, and how these treatments fit into broader recovery journeys. The findings will inform the development of patient-centred services, support shared decision-making, and help healthcare professionals deepen compassionate understanding of treatment experiences.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
18 years or older
Previously received at least one TMS and one ECT session as treatment for major depression
Conversational in the English language
Capacity to give informed consent to take part in this study
Disqualifiers
Participants may be excluded at the judgement of the PI if it is felt that the participant is at high risk of significant emotional distress from taking part in the interviews at this time
Trial population
Adults who have received at least one session of TMS in Nottingham or Liverpool, who have also received at least one session of ECT, both intended to treat an episode of major depression
Trial design
Case-only
Prospective
Treatments tested in this trial
There is no intervention in this observation study (qualitative interviews about past treatment experiences)
Other interventionThere is no intervention in this observation study (qualitative interviews about past treatment experiences)
Treatment groups
Trial outcomes
Primary outcomes
Co-created narratives and associated themes
Sponsors and contacts
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University of Nottingham
Lead sponsor
Mersey Care NHS Trust
Collaborator
This trial is not recruiting at the moment. You can still explore other options: