The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of stimulation. The main hypotheses are:
* NDD participants and children exhibit higher intra-individual variability than other participants * intra-individual neurophysiological variability is correlated to behavioral, psychological and learning profiles
Participants in this study will:
* be recorded for EEG and other neurophysiological parameters while exposed to sensory stimulations, to quantify sensory neurophysiological variability * perform behavioral tests and fill out questionnaires, to establish the behavioral and psychological profile * train for perceptual learning, to measure learning abilities
These evaluations will be split in 3 visits spread on a maximum of 3 months, and training for learning will be done at home in between 2 visits.
Social security affiliation
Free and written informed consent from the participants (Neurotypical Adults, NDD Adults without judicial protective measures), or their tutor or legal representant(s) (other participants)
Age between 6 and 12 years included (Children) or between 18 and 45 years included (Adults)
For NDD participants: NDD diagnosis by a qualified medical professional, according to DSM-4, DSM-5, ICD-10 or ICD-11 criteria
Participants with no data to evaluate Outcome 1
Participants will be adults between 18 and 45 years old and children between 6 and 12 years old, with or without a Neurodevelopmental Disorder.
Case-control
Prospective
Not listed
Amplitude of central neurophysiological responses to sensory stimulations
Amplitude (in micro-volts) of event-related potentials
Latency of central neurophysiological responses to sensory stimulations
Latency (in milli-seconds) of event-related potentials
Variability of central neurophysiological responses to sensory stimulations
Intra-individual variability (in percentage) of event-related potentials
Visual perceptual learning performance
Discrimination performance (in percentage) for visual delayed-matching to sample task
Auditory perceptual learning performance
Discrimination performance (in percentage) for auditory delayed-matching to sample task
Behavioral sensory profile
Score (in absolute score) for psychomotor evaluation (Échelle des Particularités Sensori-psychomotrices dans l'Autisme)
Sensory profile questionnaire
Score (in absolute score) for sensory questionnaire (Dunn Sensory Profile)
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University Hospital, Tours
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Collaborator
