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Individualized rTMS for Motor Recovery in Stroke Patients

ConditionsStrokeTranscranial Magnetic Stimulation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20+
SponsorNational Taiwan University Hospital

About this trial

This study aimed to aim to investigate the efficacy of individualized rTMS according to lateralization index on motor recovery and cortical excitability in subacute stroke patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Unilateral ischemic or hemorrhagic stroke

Stroke within 3 months

Medical Research Council Scale for Muscle Strength in upper limb ≤ 3

No previous stroke, seizure, dementia, Parkinson's disease or other degenerative neurological diseases.

Disqualifiers

Previous stroke, traumatic brain injury, brain tumor

With central nervous system disease (spinal cord injury, Parkinson's disease)

Any contraindication to rTMS (seizure, alcoholism, metal implant, pacemaker)

Patients unable to cooperate the treatment

Trial design

Design model

Parallel

Treatments tested in this trial

  • Repetitive transcranial magnetic stimulation

    Device

    Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology. High and low frequencies of rTMS could modulate the excitability of the cerebral cortex.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: individualized rTMSExperimental treatment 1 intervention
Group B: Traditional rTMSActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Fugl-Meyer Assessment

Fugl-Meyer Assessment motor function set, score: 0-66, higher scores indicate a better outcome.

Time frame
12 weeks post intervention

Secondary outcomes

1

Medical Research Council (MRC) Scale for Muscle Strength

Medical Research Council (MRC) Scale for Muscle Strength, assessing muscle strength from Grade 5 (normal) to Grade 0 (no visible contraction).

Time frame
1 week, 4 weeks, 12 weeks post intervention
2

National Institutes of Health Stroke Scale

National Institutes of Health Stroke Scale, The maximum possible score is 42, with the minimum score being a 0. Higher scores indicate a worse outcome.

Time frame
1 week, 4 weeks, 12 weeks post intervention
3

Barthel Index

Barthel Index, score 100-0. Higher scores indicate a better outcome.

Time frame
1 week, 4 weeks, 12 weeks post intervention
4

Modified Rankin Scale

Modified Rankin Scale, score from 0 to 6. Higher scores indicate a worse outcome.

Time frame
1 week, 4 weeks, 12 weeks post intervention

Other outcomes

Locations

1

Map coordinates are unavailable for these locations. Locations are shown below instead.

National Taiwan University HospitalRecruiting100, Taipei County, TaipeiTaiwanTaiwan

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

National Taiwan University Hospital

Lead sponsor

Source ClinicalTrials.gov
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