Inflammation, Diabetes, Ethnicity and Obesity Cohort
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorUniversity of California, San Francisco
About this trial
Obesity affects over one third of US adults (\>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of obesity and its consequences is one of the most important problems of our time.
In this proposed study, investigators will recruit participants from a wide range of body mass index (BMI), ethnicity and Diabetes risk to collect data and blood, stool and adipose tissue samples in the San Francisco bay area.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Participants will be healthy individuals between the ages of 18-75 years. These cutoffs are designed to allow inclusion of postmenopausal women, and younger/more active patients who are increasingly undergoing bariatric surgery.
Patients with either diabetes type 2 or the metabolic syndrome will be included in the cohort.
Disqualifiers
Participants with chronic kidney disease (> stage 4)
Autoimmune/inflammatory disease (e.g., Lupus, Ulcerative Colitis, etc.)
Unstable angina, New York (NY) class III or IV congestive heart failure or myocardial infarction within 3 months of entry
Clinically significant liver disease (e.g. Cirrhosis or liver failure)
Trial population
IDEO Cohort participants
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
350 Participants
are grouped into 1 trial groupGroup A: IDEO Cohort
Trial outcomes
Primary outcomes
1
Complete recruitment of IDEO cohort participants to spur novel and creative interactions between investigators that have transformative potential in obesity research.
Number of biological samples collected
Time frame
7 yearsSecondary outcomes
1
Adipose tissue inflammation and fibrosis
Quantification of pro-fibrotic and pro-inflammatory markers in the visceral and subcutaneous adipose tissue
Time frame
7 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov