Influence of Hypoxic Induced Factors in Patients With Hereditary Hemorrhagic Telangiectasia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Essen
About this trial
Patients with hereditary hemorrhagic telangiectasia (HHT) suffer from an inherited disorder leading to systemic vascular malformations. Mutations in several genes of the transforming growth factor (TGF)-β superfamily pathway influence angiogenesis in patients with HHT. The genetic loss of ALK1 or ENG alone are not sufficient to induce AVMs; environmental insults that could trigger angiogenesis (e.g. wounding) are also needed. In this study it will be analyzed if hypoxic induced factors could have an influence on the disease HHT.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
diagnosed HHT (genetic testing and/ or fulfill at least 3 Curacao Criteria)
older than 17 years
ability to consent
Disqualifiers
if inclusion Criteria are not met
Trial population
Patients with diagnosed hereditary hemorrhagic telangiectasie (HHT)
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
hypoxic induced factors
Other interventionhypoxic induced factors analyzed in blood sample
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: HHT1 intervention
Group B: control1 intervention
Trial outcomes
Primary outcomes
1
Differences in hypoxic induced factors
Differences in hypoxic induced factors analyzed in blood samples from patients with HHT and healthy controls
Time frame
12 monthsSecondary outcomes
1
Correlation of level of hypoxic induced factors and disease severity
Correlation of level of hypoxic induced factors in patients' blood sample and their disease severity
Time frame
12 monthsSponsors and contacts
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Source ClinicalTrials.gov