Influence of TMS on Attention Modulation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAuburn University

About this trial

The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol.

Participation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan.

People in the Auburn/Opelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

MRI Contraindications

Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)

Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr

Hearing loss, including tinnitus, that might be made worse by MRI or TMS

Trial design

Design model

Crossover

Treatments tested in this trial

  • TMS

    Device

    TMS will be administered in a pattern that is either excitatory or inhibitory.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: TMS AExperimental treatment 1 intervention
Group B: TMS BActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in attention switching

MRI Task- analysis of behavioral data

Time frame
Baseline, immediately following TMS A, immediately following TMS B
2

Change in sociomoral attention switching

MRI Task- analysis of behavioral data

Time frame
Baseline, immediately following TMS A, immediately following TMS B
3

Change in cue reactivity

MRI Task- analysis of behavioral data

Time frame
Baseline, immediately following TMS A, immediately following TMS B

Secondary outcomes

1

Change in brain activity attention switching

MRI Task- analysis of imaging (fMRI) data

Time frame
Baseline, immediately following TMS A, immediately following TMS B
2

Change in brain activity during sociomoral attention switching

MRI Task- analysis of imaging (fMRI) data

Time frame
Baseline, immediately following TMS A, immediately following TMS B
3

Change in brain activity during cue reactivity

MRI Task- analysis of imaging (fMRI) data

Time frame
Baseline, immediately following TMS A, immediately following TMS B

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Auburn University

Lead sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator