This study aims to compare the clinical and radiographic effectiveness of injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical therapy (MINST) versus MINST alone in the management of class II furcation defects.
Patients of both genders >18 years old, medically free of systemic diseases affecting periodontal regeneration.
Diagnosis of stage III, grade B periodontitis (according to the AAP/EFP classification 2018) with the presence of class II furcation defect in either the maxillary (buccal) or mandibular arch (buccal or lingual) as determined by clinical evaluation and confirmed by radiographic evaluation.
Gingival margin and interdental bone positioned coronally to the furcation entrance.
Commitment to maintenance visits and follow-up.
Patients suffering from any systemic diseases that may affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc;
Patients that received periodontal surgical treatments in the past 12 months.
Smoking (current or in past 5 years)
Prolonged treatment with antibiotics or anti-inflammatory agents within 6 months prior to periodontal therapy.
Parallel
Minimally invasive non-surgical technique (MINST)
Procedure/SurgeryPatients will receive minimally invasive non-surgical technique (MINST) alone
Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Procedure/SurgeryPatients will receive minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Change in Radiographic Bone Fill at the Furcation Site
Radiographic bone fill at the furcation site will be assessed using cone-beam computed tomography (CBCT). The analysis will include measurement of the filled bone volume (FBV) at the furcation area using segmentation.
Change in Horizontal Clinical Attachment Level
Horizontal clinical attachment level will be assessed using periodontal probing at baseline and 6 months after treatment.
Change in Vertical Clinical Attachment Level
Vertical clinical attachment levels will be assessed using periodontal probing at baseline and 6 months after treatment.
Change in Probing Pocket Depth
Probing pocket depth (PPD) will be measured in millimeters from the gingival margin to the base of the periodontal sulcus at six sites per tooth using a UNC-15 periodontal probe. Measurements will be recorded at baseline and 6 months after treatment.
Change in Gingival Margin Location
The location of the gingival margin will be assessed by measuring the distance from the cemento-enamel junction (CEJ) to the gingival margin. Measurements will be recorded at baseline and 6 months after treatment.
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