This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.
Patients of both genders >18 years old, medically free of systemic diseases affecting periodontal regeneration.
Diagnosis of 'periodontitis' stage III (grades B or C).
Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible.
Presence of comparable bilateral two- or three-walled intrabony defects [probing pocket depth (PPD), > 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph] not in a furcation-involved tooth.
Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc.
Pregnant and lactating women
Current use of any form of tobacco.
Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.
Parallel
Minimally invasive non-Surgical technique
Procedure/SurgeryPatients will receive minimally invasive non-Surgical technique (MINST) alone
Minimally invasive non-Surgical technique + platelet-rich fibrin
Procedure/SurgeryPatients will receive minimally invasive non-Surgical technique (MINST)+ injectable platelet-rich fibrin (i-PRF) injection
Presence of comparable bilateral-walled intrabony defects
Assessment of intrabony defect fill radiographically will be measured using the standardized paralleling technique. Presence of comparable bilateral-walled intrabony defects (PPD, \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph) not in a furcation-involved tooth.
Clinical attachment level
Clinical attachment level (CAL) will be measured in millimeters from the cemento-enamel junction (CEJ) to the base of the periodontal sulcus at 6 sites per tooth
Interproximal probing depth
Probing depth (PD) will be measured in millimeters from the gingival margin to the base of the periodontal sulcus at 6 sites per tooth
Gingival margin
Gingival margin will be measured from the cemento-enamel junction (CEJ).
Bleeding on probing
Bleeding on Probing (BoP) will be measured using papillary bleeding index that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus
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