Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age45-65
SponsorInstituto de Cardiologia do Rio Grande do Sul

About this trial

Existing data points to relevant beneficial effects of respiratory exercises on cardiovascular health, with special regards to decreases on arterial pressure and improves on autonomic and vascular profiles, though mechanistics of such results have not yet been cleared. Among the available ways to perform respiratory exercises, there is the highly recommended Inspiratory Muscle Training (IMT) and slow breathing exercises like Yoga pranayamas. Lately, the development of new technologies has allowed the use of Apps to perform respiratory exercises. This study will be take the just developed CardioBreath®App to validate it as a tool to perform respiratory exercises. Therefore, it will be compared to IMT on cardiac vagal modulation and pulse wave velocity on normotensive post menopause women.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Follicle Stimulating Hormone (FSH)>35mui/ml

minimum 12 months amenorrhea

sedentary life style (less than 150 minutes per week of exercise)

Disqualifiers

Hypertension

Diabetes

Obesity

Use of Betablockers

Trial design

Design model

Sequential

Treatments tested in this trial

  • CardioBreathApp

    Device

    Respiratory exercises performed with CardioBreathApp prescription and voice and visual guidance

  • IMT PowerBreath

    Device

    Inspiratory Muscle Training (IMT) performed with 30% load based on Maximal Inspiratory Pressure

  • IMT PowerBreath Placebo

    Device

    Inspiratory Muscle Training (IMT) without load

Treatment groups

24 Participants
are divided into 3 treatment groups
Group A: IMT PowerBreathActive comparator 1 intervention
Group B: IMT PowerBreath PlaceboPlacebo comparator 1 intervention
Group C: CardioBreathAppActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Cardiovascular autonomic control by heart rate variability(HRV)

High Frequency (HF) component of HRV (ms2 = squared milliseconds) as measure of vagal modulation

Time frame
30 minutes

Secondary outcomes

1

Carotid -femoral pulse wave velocity (Complior)

Reduction of carotid -femoral pulse wave velocity (m/s)

Time frame
10 minutes

Other outcomes

1

Respiratory rate by Pneumotrace respiratory belt

Respiratory rate in cycles per minute (CPM)

Time frame
30 minutes along with Finometer
2

Diaphragm Thickness by ultrasound

Increase diaphragm thickness (mm)

Time frame
5 minutes

Sponsors and contacts

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