Health TrialsbyHealthPanel

Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD)

ConditionsObsessive - Compulsive DisorderTic Disorder, Chronic Motor or VocalTic DisordersTic Disorder, Combined Vocal and Multiple MotorTourette DiseaseTourette DisorderTourettes SyndromeGilles de la Tourette Syndrome
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity College London Hospitals

About this trial

Obsessive-Compulsive Disorder and Tic Disorders frequently co-occur, and a subgroup of patients - those with a Tourettic Subtype of OCD (TOCD) - present with concurrent obsessive-compulsive and tic symptoms. Existing psychological interventions typically target one condition or the other, but rarely both together. This study aims to test whether a combined psychological therapy integrating Exposure and Response Prevention (ERP) and Habit Reversal (HbRT) is more effective at reducing symptoms than either therapy delivered alone, in adults with TOCD.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18 years or older

All genders

Disqualifiers

Substance misuse

Current diagnosis of a personality disorder

Schizophrenia

Bipolar disorder

Trial design

Design model

Parallel

Treatments tested in this trial

  • Exposure and Response Prevention (ERP)

    Behavioral

    Exposure and Response Prevention (ERP) is a behavioural intervention that involves gradual and systematic exposure to obsessional fears, distress, sensory discomfort, premonitory urges, and "not-just-right" experiences while refraining from compulsions, avoidance, reassurance seeking, and other safety behaviours. Treatment is delivered individually over 12 weekly 50-minute sessions, either face-to-face or remotely.

  • Habit Reversal Training (HbRT

    Behavioral

    Habit Reversal Training (HbRT) is a behavioural intervention that includes awareness training, identification of premonitory urges and antecedents to tic expression, development and practice of competing responses, and strategies to generalise skills across settings. Treatment is delivered individually over 12 weekly 50-minute sessions, either face-to-face or remotely.

  • Psychoeducation and Supportive Intervention

    Behavioral

    Psychoeducation and Supportive Therapy consists of structured education about obsessive-compulsive disorder, tic disorders, Tourettic obsessive-compulsive disorder, stress, and wellbeing, together with supportive discussion and general problem-solving. The intervention does not include Exposure and Response Prevention, Habit Reversal Training, or other targeted behavioural techniques. Treatment is delivered individually over 12 weekly 50-minute sessions, either face-to-face or remotely.

Treatment groups

40 Participants
are divided into 4 treatment groups
Group A: Combined Exposure and Response Prevention and Habit ReversalExperimental treatment 2 interventions
Group B: Standardised Exposure and Response PreventionActive comparator 1 intervention
Group C: Standardised Habit ReversalActive comparator 1 intervention
Group D: Psychoeducation / Supportive InterventionActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change From Baseline in Yale-Brown Obsessive Compulsive Scale Total Score

Obsessive-compulsive symptom severity will be assessed using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Total scores range from 0 to 40, with higher scores indicating greater obsessive-compulsive symptom severity. Change from baseline will be assessed at Week 12 and Week 24.

Time frame
Baseline, Week 12 and Week 24
2

Change From Baseline in Yale Global Tic Severity Scale Total Tic Severity Score

Tic symptom severity will be assessed using the Yale Global Tic Severity Scale (YGTSS) Total Tic Severity Score. Scores range from 0 to 50, with higher scores indicating greater tic symptom severity. Change from baseline will be assessed at Week 12 and Week 24.

Time frame
Baseline, Week 12 and Week 24

Secondary outcomes

1

Change From Baseline in Yale Global Tic Severity Scale Global Severity Score

Overall tic symptom severity and tic-related impairment will be assessed using the Yale Global Tic Severity Scale (YGTSS) Total Score. The Global Score is calculated by summing the Total Tic Severity Score (0-50) and the Impairment Score (0-50), resulting in a global score ranging from 0 to 100. Higher scores indicate greater overall tic severity and impairment. Change from baseline will be assessed at Week 12 and Week 24.

Time frame
Baseline, Week 12 and Week 24

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University College London Hospitals

Lead sponsor

University College, London

Collaborator

Source ClinicalTrials.gov
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