Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk
ConditionBreast Carcinoma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-100
SponsorMayo Clinic
About this trial
The purpose of this research is to better understand how benign breast diseases might lead to breast cancer, focusing on genetic factors and including a diverse range of participants to improve future diagnosis and treatment.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Female patients, ages 18 to 100 years
Had a benign breast biopsy at Mayo Clinic between 2002-2022
Disqualifiers
All male patients
Prior or concomitant diagnosis of BC
Diagnosis of BC within six months of benign breast disease
Denial of research authorization
Trial population
Women who had a benign breast biopsy at Mayo Clinic between 2002 and 2022.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Non-Interventional Study
Other interventionNon-interventional study
Treatment groups
4,500 Participants
are divided into 1 treatment groupGroup A: Observational1 intervention
Trial outcomes
Primary outcomes
1
Pathologic features
Will examine pathologic features from benign tissue to define features related to breast cancer (BC) risk.
Time frame
Baseline (collection of blood or saliva sample)2
Radiologic features
Will examine radiologic features from mammographic images at time of benign breast disease (BBD) to define features in mammogram images that predict BC risk among women who have a history of BBD. We will also assess whether these features predict BC risk among women without a history of BBD.
Time frame
Baseline (collection of blood or saliva sample)3
Molecular features
Will examine molecular features to understand how molecular features, including DNA damage and repair work in the breast tissues of women with BBD and how this might relate to risk of developing BC
Time frame
Baseline (collection of blood or saliva sample)Sponsors and contacts
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Source ClinicalTrials.gov