Health TrialsbyHealthPanel

Interaction Between Early Trauma and Odor-induced Dopamine Release

ConditionTrauma, Psychological
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorHôpital le Vinatier

About this trial

This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Aged 18 years or older

Have been selected based on the Childhood Trauma Questionnaire score

Non-smoker

Be able to speak and read French

Disqualifiers

A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and/or sinus disease,

Be on medication, with the exception of oral contraceptives

Pregnant or breast-feeding woman (check with urine pregnancy tests);

Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);

Trial design

Design model

Parallel

Treatments tested in this trial

  • High score at Childhood Trauma Questionnaire.

    Other intervention

    In the "presence of early trauma" arm, 15 participants are recruited based on a high Childhood Trauma Questionnaire total score.

  • Low score at Childhood Trauma Questionnaire.

    Other intervention

    In the "absence of early trauma" arm, 15 participants are recruited based on a low Childhood Trauma Questionnaire total score.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Presence of early traumaOther 1 intervention
Group B: Absence of early traumaOther 1 intervention

Trial outcomes

Primary outcomes

1

Dopamine transmission measured with positron emission tomography

Subcortical dopaminergic transmission will be analyzed, using \[11C\]raclopride PET activity (D2 receptor antagonist)

Time frame
24 months

Secondary outcomes

1

Odor hedonic appreciation.

The pleasantness of the odors presented will be assessed on a scale of 1 to 9.

Time frame
24 months
2

Functional brain connectivity.

Resting-state functional connectivity assessed with fMRI.

Time frame
24 months
3

Effective brain connectivity

Effective brain connectivity will be assessed using a dual-coil TMS protocol that stimulates the motor cortex and dorsolateral prefrontal cortex during odor presentation. Measurement of the amplitude of the motor response reflects the connectivity between these two regions of interest.

Time frame
24 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Hôpital le Vinatier

Lead sponsor

Source ClinicalTrials.gov
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