Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis

ConditionEndocarditis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Henri Becquerel

About this trial

The objective of this study is to determine if early parametric positron emission computed tomography is useful to diagnose cardiac prosthetic valve infections.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age superior to18 years,

Effective contraception for women of childbearing age or negative pregnancy test on the day of the exam

Good general condition. WHO ≤ 1

Suspicion of endocarditis on a prosthetic heart valve implanted more than 3 months ago

Disqualifiers

Presence of an active cancer in the previous three years

Pregnancy or breastfeeding

Poorly controlled diabetic patients

Protected adults (under guardians or curators)

Trial design

Design model

Single group

Treatments tested in this trial

  • Parametric positron emission computed tomography

    Device

    Patients will undergo parametric positron emission computed tomography in 15 days after the labeled polynuclear scintigraphy

Treatment groups

30 Participants
are divided into 1 treatment group
Group A: Parametric positron emission computed tomographyExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Determination of diagnostic value of parametric positron emission computed tomography

area under the curve of the Ki parameter (and the Vd parameter) as a function of the presence of endocarditis diagnosed during the multidisciplinary consultation meeting at 3 months

Time frame
3 months

Secondary outcomes

1

Correlation between parametric positron emission computed tomography and scintigraphy with labelled leukocytes

comparison between diagnosis established by parametric positron emission computed tomography and scintigraphy with labelled leukocytes

Time frame
3 months

Other outcomes

Sponsors and contacts

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