About this trial
We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days about a mild traumatic brain injury (MTBI). Our first objective was to evaluate the diagnostic performance of seven tesla MRI runned at seven days after MTBI among patients presenting a PCS.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Mild traumatic brain injury with glascow included between 13 and 15, with indication of scan
possibilty of performing an MRI at 7 days
Patient able to get to MRI at Day 7
Free consentement to the study
Disqualifiers
Patient does not hospitalized about head trauma
Inhability to move out for run the seven day MRI
Contraindication for MRI
Patient having already consulted the emergency for head trauma requiring imaging
Trial design
Single group
Treatments tested in this trial
7T MRI
Other interventionSeven tesla brain MRI (7T MRI) at day 7 in patients suffering from post concussionnal symptoms after mild traumatic brain injury admitted to emergency departement of Poitiers CHU (University Hospital
Treatment groups
Trial outcomes
Primary outcomes
Determine the diagnostic performance of 7 Tesla MRI performed of mild head trauma for the occurrence of post-concussion syndrome (PCS)
appearance of diffuse axonal lesions
Secondary outcomes
Evaluate the S100b dosed at admission is correlated with the occurrence of post concussion syndrome after a mild head injury.
Value of S100b dosed at admission
Evaluate the S100b dosed at admission is correlated with diffuse axonal lesion
appearance of diffuse axonal lesion and S100b dosed at admission
Assess the quality of life of patients suffering for post-cocussion syndrome
quality of life EQ-5D-5L questionary (score ranging from levels 1, 2, 3 (without problems) and levels 4,5 (with problems) and GOS-E scales (score ranging from 1.1 (good recovery) to 5 (death).
Correlation the association between the alteration of the anisotropy fraction (AF) and post-concussion syndrome on the MRI diffusion tensor (DTI) sequence
Focal alteration of AF data on a DTI sequence.
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