Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Rouen

About this trial

The objective of the study is to evaluate the prognostic performance of the chair lift test in the initial assessment of the severity of non-severe pulmonary embolism in hospitalized patients, in comparison with the current pulmonary embolism risk stratification score using the sPESI score refined by the use of cardiac biomarkers and right ventricular dysfunction

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of pulmonary embolism according to clinical algorithm, confirmed by thoracic angioscan or ventilation perfusion (V/P) scan,

Non-serious pulmonary embolism, not requiring intensive care (thrombectomy or fibrinolysis not considered).

sPESI score ≥ 1 [or = 0 with elevated troponin or presence of markers of VD dysfunction, or = 0 with need for hospitalization due to comorbidities unrelated to PE (social isolation, comprehension disorders, intercurrent infection, chronic renal failure, advanced cancer...)

Patients with no contraindications to chair lift testing (no O2 at the time of testing).

Disqualifiers

sPESI score = 0 with outpatient referral.

Diagnostic confirmation of Pulmonia Embolism by thoracic angioscan or scintigraphy more than 24h after suspicion of diagnosis.

Hospitalization > 24h after introduction of anticoagulation, with subsequent confirmation by scintigraphy.

Any sign of serious Pulmonia Embolism, requiring hospitalization in an intensive care unit.

Trial design

Design model

Single group

Treatments tested in this trial

  • chair lift test

    Other intervention

    repetitions of the sit-stand position at a self-timed speed (safe and comfortable) as many times as possible for 1 minute

Treatment groups

180 Participants
are divided into 1 treatment group
Group A: chair lift testExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the one-minute chair rise test in comparison with the gold standard refined by the use of cardiac biomarkers and right ventricular dysfunction

Time frame
1 day

Secondary outcomes

1

Troponin measurement

Time frame
1 day
2

Presence or absence of post-pulmonary embolism dyspnea

Time frame
6 months
3

Overall survival

Time frame
6 months

Other outcomes

Sponsors and contacts

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