Comparing the effect of HBOT and IHT on aerobic performance of athletes.
Vo2max above 3500 ml or Vo2max/kg above 50 ml/kg
Age 18-45
Subjects are active aerobic athletes, training regularly more than 4 exercise sessions per week.
Subject willing and able to read, understand and sign an informed consent
Inability to attend scheduled clinic visits and/or comply with the study protocol
Active malignancy
Active smokers
Previous treatment of HBOT for any reason prior to study enrollment.
Parallel
Hyperbaric Oxygen Therapy - HBOT
DeviceEach session will include exposure of 90 minutes to 100% at 2 ATA, with 5 minutes air breaks every 20 minutes
Intermittent Hypoxic Training - IHT
DeviceEach session lasts 60 minutes of 15.2% oxygen at 1.0 ATA. Subjects will be training according to individualized training protocol.
Cardiopulmonary exercise test (CPET)
CPET determines the gas exchange dynamics that is expected to change through the intervention
Cardiopulmonary exercise test (CPET)
CPET determines the gas exchange dynamics that is expected to change through the intervention
Time To Exhaustion
The test will be conducted on the SRM high performance ergometer on 105% of the maximal aerobic power
Wingate 30 seconds anaerobic test
The Wingate Anaerobic Test (WAnT) is conducted on the SRM high performance ergometer.
Muscle biopsy for mitochondrial function
Participants will undergo a muscle biopsy, muscle sample will be analyzed using the Oxygraph (Oroboros Inc, Austria) for oxygen respiratory function, as well as staining for mitochondrial proteins
Cognitive Function
Cognitive function will be evaluated using the Neurotrax computerized cognitive assessment and the Cambridge Neuropsychological Test Automated Battery (CANTAB).
Cognitive Function under exercise
Participants will be asked to pedal on a bike on workload correlated to 85% of the second ventilatory threshold obtained during the CPET and will simultaneously perform a Stroop test using the EncephalApp Stroop Test application on a tablet.
Whole-brain quantitative perfusion imaging
Whole-brain quantitative perfusion imaging will be performed using Dynamic susceptibility contrast (DSC)-MRI technique
Brain microstructure MRI evaluation
Fractional anisotropy (FA) and Mean diffusivity (MD) will be evaluated using diffusion tensor imaging (DTI) MRI protocol
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