Health Trials

Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)

ConditionHypothyroidism
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAndijan State Medical Institute

About this trial

This hospital-based observational cross-sectional study aims to investigate the morphometric characteristics of internal organs and the morphofunctional status of the musculoskeletal system in adult patients with previously diagnosed hypothyroidism. The study will evaluate ultrasonographic morphometric characteristics of the liver, pancreas, and kidneys, as well as anthropometric and functional characteristics of the musculoskeletal system. Associations between these outcomes and clinical characteristics, anthropometric parameters, physical activity, and laboratory findings will also be assessed. The study is expected to identify accessible clinical, anthropometric, and functional markers associated with morphometric and musculoskeletal changes in patients with hypothyroidism, thereby improving risk assessment and early detection of systemic involvement.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 18-59 years.

Previously established diagnosis of hypothyroidism.

Receiving routine outpatient or inpatient care at participating healthcare institutions.

Ability to undergo ultrasonographic, anthropometric, and functional assessments.

Disqualifiers

Pregnancy or lactation.

History of thyroid malignancy.

Acute infectious or inflammatory disease at the time of enrollment.

Severe decompensated cardiovascular, hepatic, or renal disease preventing study procedures.

Trial population

Adult patients with a previously established diagnosis of hypothyroidism receiving routine medical care at participating healthcare institutions.

Trial design

Design model

Cohort

Time perspective

Cross-sectional

Treatments tested in this trial

  • Comprehensive Morphometric and Functional Assessment

    Diagnostic test

    Participants will undergo a standardized diagnostic assessment including clinical evaluation, anthropometric measurements, ultrasonographic examination of the liver, pancreas, and kidneys, functional

Treatment groups

500 Participants
are divided into 1 treatment group
Group A: Patients With Hypothyroidism1 intervention

Trial outcomes

Primary outcomes

1

Liver Longitudinal Diameter

The longitudinal diameter of the liver will be measured by abdominal ultrasonography according to the standardized study protocol. The measurement will be recorded in centimeters (cm).

Time frame
Baseline
2

Pancreatic Head Thickness

The anteroposterior thickness of the pancreatic head will be measured by abdominal ultrasonography according to the standardized study protocol. The measurement will be recorded in millimeters (mm).

Time frame
Baseline
3

Kidney Length

The longitudinal length of each kidney will be measured by ultrasonography according to the standardized study protocol. Measurements will be recorded in millimeters (mm).

Time frame
Baseline
4

Handgrip Strength

Muscle strength will be assessed using a calibrated handgrip dynamometer. Maximum grip strength will be recorded in kilograms (kg). Higher values indicate greater muscle strength.

Time frame
Baseline

Secondary outcomes

1

Five Times Sit-to-Stand Test

Lower-extremity physical function will be assessed using the Five Times Sit-to-Stand Test. The time required to complete five consecutive chair stands without using the arms will be recorded in seconds. Longer completion times indicate poorer physical performance.

Time frame
Baseline
2

Body Mass Index

Body mass index will be calculated as body weight divided by height squared and expressed in kilograms per square meter (kg/m²).

Time frame
Baseline
3

Waist Circumference

Waist circumference will be measured using a standardized anthropometric technique and recorded in centimeters (cm).

Time frame
Baseline
4

Calf Circumference

Calf circumference will be measured at the point of maximum circumference and recorded in centimeters (cm).

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Andijan State Medical Institute

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: