Internal Spermatic Vein Histopathology in Patients Undergoing Varicocelectomy
ConditionVaricocele
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
AgeNot listed
SponsorAssiut University
About this trial
Varicocele is an enlargement of the veins around the testicle and may affect male fertility. This prospective observational study will include men with varicocele who are undergoing varicocelectomy. The study aims to examine whether changes in the structure of the internal spermatic veins are related to clinical findings, semen analysis results, and scrotal duplex ultrasound findings.
During varicocelectomy, vein tissue that is removed as part of the surgical procedure will be collected and examined under a microscope. Digital image analysis will also be used to measure different features of the vein wall, including its thickness and the amounts of smooth muscle and collagen.
In participants undergoing surgery for varicocele on both sides, the findings from the left and right spermatic veins will also be compared. The study does not assign participants to varicocelectomy; the decision to perform surgery is based on their clinical care.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Male patients with clinically palpable varicocele.
Scheduled for varicocelectomy.
Preoperative scrotal duplex ultrasonography available.
Preoperative semen analysis available.
Disqualifiers
Previous varicocelectomy on the affected side.
Previous major scrotal or testicular surgery affecting the study side.
Obstructive causes of azoospermia, when applicable to the semen analysis component.
Hormonal treatment that may significantly alter semen parameters.
Trial population
Male patients with clinically palpable varicocele who are scheduled to undergo varicocelectomy at Assiut University Hospitals. Eligible participants will undergo preoperative clinical assessment, semen analysis, and scrotal duplex ultrasonography. Internal spermatic vein specimens excised during varicocelectomy will undergo histopathological and quantitative digital morphometric assessment.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Correlation of Internal Spermatic Vein Histopathological Parameters With Clinical, Duplex Ultrasound, and Semen Parameters
Internal spermatic vein histopathological parameters will be quantified using QuPath digital morphometric analysis and correlated with prespecified clinical, duplex ultrasound, and semen parameters using Pearson or Spearman correlation, as appropriate. Histopathological parameters include total wall area, wall thickness, wall-thickness-to-lumen-diameter ratio, smooth muscle area (% of wall and % of media), collagen area (% of wall and % of adventitia), and muscle-to-collagen ratio.
Time frame
Preoperatively and at the time of varicocelectomyLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: