To prospectively assess the incidence of peritoneal carcinomatosis for women with isolated STIC (serous tubal intraepithelial carcinoma). Moreover, to identify histopathological characteristics of STIC which are reproducible and associated to the risk of peritoneal carcinomatosis and to report the findings of additional diagnostics.
Women
Bilateral salpingectomy (with or without oophorectomy)
A serous tubal intraepithelial carcinoma at histopathological review
Invasive cancer at initial surgery or pathological examination (either macroscopic and/or microscopic)
For the retrospective cohort: All women with STIC diagnosed between 2015 and start of the prospective study are identified. Data up until that time-point will be collected. At the end of the data collection follow-up will be updated on the women in the retrospective cohort. For the prospective cohort: All consecutive women with isolated STIC from participating centres are informed on the study and requested to participate.
Cohort
Prospective
No intervention, only registration
Other interventionNo intervention, only registration
The risk for peritoneal carcinomatosis in women with isolated STIC
Risk factors
Risk for PC in relation to patient characteristics such as age at diagnosis and presence of a genetic pathogenic variant.
Histopathological characteristics
Identification of histopathological characteristics of STIC which are reproducible and associated to the risk of PC.
Additional diagnostics
To report findings at additional diagnostics (ie. imaging, staging surgery, CA125).
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