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Interval Training and Cardio-metabolic Health in Overweight/Obese Girls

ConditionsExercise OvertrainingEnjoymentCardiometabolic SyndromeObesity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age12-15
SponsorAssociation Tunisienne d'Etude & de Recherche sur l'Athérosclérose

About this trial

The main purpose of this study is to compare the impact of 12-week moderate-intensity interval training (MIIT) versus combined MIIT with high-intensity interval training (HIIT) on physical fitness, cardio metabolic, lipidomic, hematological and psychological characteristics in young overweight/obese girls.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Female gender,

Overweight or obese according to the BMI classification,

Age, 12 to 15 years,

Personal or parental/guardian written consent

Disqualifiers

Severe infectious or inflammatory diseases,

Irregular menstrual cycles

Participation in organized exercise training in the last 6 months or additional physical -

recreational activities, except physical education classes.

Trial design

Design model

Parallel

Treatments tested in this trial

  • MIIT

    Other intervention

    12-week supervised exercise program consisting of moderate-intensity interval training (MIIT) MIIT: 3 series of 4-8 repetitions of 30-s of work at 70-75% of MAS and 30-s of active recovery at 50% of MAS. 3 exercise sessions per week. Additionally, participants receive no individualized nutritional counseling.

  • MIIT + HIIT

    Other intervention

    12-week supervised exercise program consisting of moderate-intensity interval training (MIIT) (6-week) and high-intensity interval training (HIIT) (6-week). MIIT: 3 series of 4-8 repetitions of 30-s of work at 70-75% of MAS and 30-s of active recovery at 50% of MAS. HIIT: 3 series of 5 repetitions of 30-s of work at 100% of MAS and 30-s of active recovery at 50% of MAS for weeks 7-9, as well as two series of 10 repetitions of 30-s of work at 100% of MAS and 30-s of active recovery at 50% of MAS for weeks 10-12. 3 exercise sessions per week. Additionally, participants receive no individualized nutritional counseling.

  • Control group

    Other intervention

    Habitual physical activity No additional physical intervention Additionally, participants receive no individualized nutritional counseling.

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: MIITExperimental treatment 1 intervention
Group B: MIIT+ HIITActive comparator 1 intervention
Group C: Control group No trainingPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in body mass index (BMI)

measures of weight in kilograms, height in meters, calculation of BMI in kg/m\^2)

Time frame
12 weeks
2

Changes in plasma triglycerides

will be assessed using an Alinity-Abbott autoanalyzer

Time frame
12 weeks
3

Enjoyment

Enjoyment will be measured using the validated Physical Activity Enjoyment Scale. This scale was used to assess the level of enjoyment following interventions using the participants' responses to 18 items rated on a 7-point bipolar rating scale. The assessment consists of questions relateding to the enjoyment after intervention with the instruction, "Please rate how you feel about the physical activity you have been doing at the moment about the physical activity you have been doing". An overallOverall enjoyment of physical activity score was generated by summing the individual item scores. Scores ranged from 18-126, with higher scores reflecting higher levels of enjoyment.

Time frame
6 and 12 weeks

Secondary outcomes

1

Changes in Aerobic velocity

Aerobic velocity will be measured with incremental running test "the Spartacus test". This test is validated for the evaluation of aerobic capacity for obese adolescents. A rectangle of 750 m (75 × 10 m) will be created with different marks set at regular intervals, which represent the different speeds (from 7 to 18 km/h). Each stage lasts three minutes whereby the first stage is set at 7 km/h and each following stage increasing by 1 km/h. During each stage, the participant had 15 s to reach the corresponding mark and then 15 s of rest. Participants adjusted their running speed simultaneously to cones and audio beep. The test ended when the subject was no longer able to maintain the pace for two consecutive occasions or when he decided to stop due to exhaustion.

Time frame
6 and 12 weeks
2

Changes in lipidomic profile

Lipidomic profile will be assessed by measuring selected plasma polyunsaturated fatty acids (PUFAs), oxylipins and endocabnnabinnoids by LC-MS/MS method

Time frame
12 weeks
3

Changes in hematological parameters

Hematological parameters included red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocyte count , neutrophil count , lymphocyte count, monocyte count , eosinophil count and platelet count will be measured using an automated cell counter (Sysmex XN450; Norderstedt, Germany).

Time frame
12 weeks
4

Change in Heart rate

Heart rate will be recorded using a heart rate monitor (S810, Polar, Kempele, Finland) during the incremental running test "the Spartacus test".

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose

Lead sponsor

Source ClinicalTrials.gov
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