Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure

ConditionsStones, Kidney Ureteric Injury

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorAin Shams University

About this trial

in this study we are going to evaluate the efficacy of intra-ureteric aminophylline instillation in facilitating ureteric access sheath placement prior to flexible ureteroscopy in reducing ureteric injury rates.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Upper ureteric stones or renal stones < 2 cm

Disqualifiers

Ureteric strictures.

anatomic renal disorders

functional renal disorders

Urinary tract infection.

Trial design

Design model

Parallel

Treatments tested in this trial

Usage of Aminophylline prior to ureteric dilatation in Flexible uretroscopy
Drug
Intraureteric aminophylline installation prior to ureteric dilatation
Sequential teflon dilator usage prior to ureteric access sheath placement in flexible uretroscopy
Device
traditional ureteral dilators will be used. We will start by ureteral dilator 6 fr and gradually increase the size up to 12 Fr
Aminophylline instillation and Ureteral dilators together
Other intervention
Aminophylline will be instilled as in group (A) then followed by traditional ureteral dilatation as in group (B) prior to placing the ureteric access sheath

Treatment groups

129 Participants

are divided into 3 treatment groups

Group A: Group A: Aminophylline Group: Intra-ureteric instillation of aminophyllineExperimental treatment 1 intervention

Group B: Group B: Ureteral Dilator Group: Traditional ureteral dilatorsActive comparator 1 intervention

Group C: Group C: Combination Group: Aminophylline instillation and Ureteral dilatorsOther 3 interventions

Trial outcomes

Primary outcomes

The successful placement of ureteric access sheath

we will assess the successful placement of ureteric access sheath in patients (that the access sheath is passed on the guide wire till the pelviureteric junction portion of the ureter after the usage of intraureteric aminophylline or teflon dilators or the usage of both.

Time frame

intraoperative application of the access sheath

Secondary outcomes

successful stone clearance

the stone free rate following intervention

Time frame

3 weeks postoperative follow up with urinary tract multislice CT

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ain Shams University

Lead sponsor

Source ClinicalTrials.gov

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