Intranasal Platelet-Rich Plasma With or Without Topical Insulin for Post-Inflammatory Anosmia
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19+
SponsorAmin Javer
About this trial
This study evaluates whether adding topical insulin to intranasal platelet-rich plasma (PRP) improves smell recovery in adults with post-inflammatory anosmia. Participants will be randomly assigned to receive either intranasal PRP combined with topical insulin or intranasal PRP alone. Changes in olfactory function will be assessed over time to compare the effectiveness and safety of the two treatments.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosed with olfactory dysfunction despite olfactory training therapy
Loss of smell within the past 5 years
Loss of smell occurred after an infection
Platelet count is over 150,000 platelets per microliter
Disqualifiers
None
Trial design
Design model
Parallel
Treatments tested in this trial
Intranasal PRP Plus Topical Insulin
Biological/VaccineAutologous platelet-rich plasma administered intranasally with the addition of topical insulin applied to the olfactory cleft.
Intranasal PRP Plus Saline (Placebo)
Biological/VaccineAutologous platelet-rich plasma administered intranasally with saline applied in place of topical insulin as a placebo comparator.
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: PRP Plus Topical InsulinActive comparator 1 intervention
Group B: PRP AlonePlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in Olfactory Function
Change in olfactory function from baseline as measured using a validated smell identification test.
Time frame
Baseline to 12 months post-interventionLocations
Sponsors and contacts
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Amin Javer
Lead sponsor
St. Paul's Hospital, Canada
Sponsor institution
Source ClinicalTrials.gov
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