Intraosseous Versus Submucosal Dexamethsone Injection in Third Molar Surgery

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorServices Institute of Medical Sciences, Pakistan

About this trial

The goal of this clinical trial is to learn if intraosseous dexamethasone injection is better for pain and swelling postop 3rd molar surgery than submucosal dexamethasone injection. The main questions it aims to answer are:

Does intraosseous dexamethasone injection provide better pain relief and lessen facial swelling than submucosal dexamethasone injection Does intraosseous dexamethasone injection provide better interincisal opening than submucosal dexamethasone injection Researcher will compare both the techniques to see if intraosseous dexamethasone injection works better than submucosal dexamethasone injection

Participants will:

Be assessed at 3rd and 7th day postoperatively Pain will be assessed through visual analog scale score Facial measurement will be calculated as horizontal measurement plus vertical measurement divided by 2, where horizontal measurement will be taken as the distance between corner of the mouth and the earlobe attachment, and vertical measurement will be taken as distance from outer canthus of the eye to the angle of jaw.

Interincisal opening will be measured from the incisal edge of the maxillary central incisors to the incisal edge of mandibular central incisors at the midline by using millimeter ruler

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients undergoing mandibular third molar surgery

Age 18 to 35 years

Male and female

Disqualifiers

Uncontrolled systemic medical problems including diabetes and hypertension

Presence of any cyst, tumor, or other pathological condition in the molar area

Presence of any craniofacial anomalies, congenital deformities or syndromes

Patients with known adverse effects of steroid use

Trial design

Design model

Parallel

Treatments tested in this trial

  • Intraosseous dexamethasone injection after 3rd molar surgery

    Procedure/Surgery

    In Group A, patients will receive 4 mg dexamethasone intraosseous injection into the bone distal to the socket of impacted third molar immediately after extraction of the third molar and before suturing

  • Submucosal dexamethasone injection after 3rd molar surgery

    Procedure/Surgery

    In Group B, patients will receive 4 mg dexamethasone submucosal injection into the buccal vestibule opposite to the surgical site of impacted third molar immediately after surgery.

Treatment groups

76 Participants
are divided into 2 treatment groups
Group A: Group A will undergo intraosseous dexamethasone injection after 3rd molar surgeryExperimental treatment 1 intervention
Group B: Group B will undergo submucosal dexamethasone injection after 3rd molar surgeryActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Pain

Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. Pain will be assessed using visual analogue scale (VAS), which is a self-administered continuous scale comprised of a line of 10 cm in length, anchored by "no pain (score 0)" and "pain as bad as it could be (score 10)". The patient is asked to place a line perpendicular to the VAS line at the point that represents their pain intensity; and score is determined by measuring the distance between "no pain (score 0)" anchor and the patient's mark. A higher score indicates greater pain intensity

Time frame
3rd and 7th day post operatively
2

Interincisal opening

Interincisal opening will be measured from the incisal edge of the maxillary central incisors to the incisal edge of mandibular central incisors at the midline by using millimeter ruler

Time frame
3rd and 7th day post operatively
3

Facial swelling

Facial swelling is the buildup of fluid in the tissues of the face. Facial measurement will be calculated as horizontal measurement plus vertical measurement divided by 2, where horizontal measurement will be taken as the distance between corner of the mouth and the earlobe attachment, and vertical measurement will be taken as distance from outer canthus of the eye to the angle of jaw

Time frame
3rd and 7th day post operatively

Secondary outcomes

Other outcomes

Sponsors and contacts

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