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Intraperitoneal Dexmedetomidine Versus Magnesium as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy

ConditionsDexmedetomidineMagnesium SulfateLaparoscopic Cholecystectomy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorAlexandria University

About this trial

Although both dexmedetomidine and magnesium sulphate have been individually evaluated as adjuvants to local anesthetics, direct comparisons between the two agents in intraperitoneal instillation during laparoscopic cholecystectomy remain limited. Understanding their relative efficacy and safety could provide valuable guidance for optimizing perioperative analgesia in these patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged 18-60 years

ASA physical status I-II

scheduled for elective laparoscopic cholecystectomy under general anesthesia.

Disqualifiers

Known hypersensitivity to study drugs

history of cardiac arrhythmias or conduction abnormalities

severe hepatic/renal impairment

chronic opioid or analgesic use

Trial design

Design model

Parallel

Treatments tested in this trial

  • Bupivacaine 100 mg + dexmedetomidine 1 µg/kg

    Other intervention

    20 ml bupivacaine + 1 µg/kg dexmedetomidine . The total volume will be adjusted to 50 mL with saline.

  • Bupivacaine 100 mg + magnesium sulphate 50 mg/kg

    Other intervention

    20 ml bupivacaine + 50 mg/kg magnesium sulphate . The total volume will be adjusted to 50 mL with saline.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: group 1Experimental treatment 1 intervention
Group B: group 2Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Postoperative pain scores (VAS)

at rest , at movement

Time frame
postoperative day 1
2

Quality of recovery

QoR-15 questionnaire

Time frame
postoperative day 1

Secondary outcomes

1

Total postoperative opioid consumption

mg

Time frame
postoperative day 1
2

Time to first analgesic request.

minutes

Time frame
postoperative day1
3

Incidence of postoperative nausea and vomiting

number

Time frame
postoperative day 1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Alexandria University

Lead sponsor

Source ClinicalTrials.gov
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