Intravenous Lidocaine Infusion Reduce Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy

ConditionsPostoperative Pneumonia Postoperative Pulmonary Atelectasis Postoperative Pulmonary Edema

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-85

SponsorSichuan Cancer Hospital and Research Institute

About this trial

The goal of this double-center, double-blind, randomized controlled clinical trial is to compare the effect of intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy. The main question it aims to answer are whether intravenous lidocaine reduce postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy. Participants will be given intravenous lidocaine infusion in lidocaine group or placebo in control group.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

intravenous lidocaine infusion
Drug
Lidocaine bolus of 2mg/kg after induction , and then continuous infusion with 2 mg/kg/h until the participate transfer out of postoperative anesthesia care unit.
Saline
Drug
Same volume of normal saline in bolus and continuous infusion as lidocaine group.

Treatment groups

770 Participants

are divided into 2 treatment groups

Group A: lidocaine groupExperimental treatment 1 intervention

Group B: control groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

Incidence of PPCs

Pulmonary complications is defined as one or more of the following complications: respiratory infection; respiratory failure; pneumothorax;atelectasis; pleural effusion; bronchospasm; aspiration pneumonitis; anastomotic fistula

Time frame