Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age32-42
SponsorSunkaky Medical Cooperation
About this trial
The objective of this study is to investigate the efficacy of NMN supplementation in enhancing embryo developmental capacity and improving IVF success rates in patients experiencing IVF failures.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Agree to participate in the study
32-42 years old
Having at least one previous embryo implantation failure
History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria)
Disqualifiers
Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4)
Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month
Any medical contraindication of oocyte retrieval or subsequent procedures
Couples where the husband presents with severe sperm abnormalities
Trial design
Design model
Parallel
Treatments tested in this trial
NMN capsule
Dietary supplementTotal of 900mg/day for 8 weeks
Placebo
Other interventionNMN-free placebo capsules for 8 weeks
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: NMN interventionActive comparator 1 intervention
Group B: Placebo interventionPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Embryo development rate
Analyze and compare the transferable embryo rate per zygote on day 3 in between NMN and placebo intervention groups.
Time frame
Up to 8 weeks post-intervention2
Changes in metabolic status
Analyze and compare the NAD+/NADH level in serum and follicular fluid in both NMN and placebo groups
Time frame
Up to 8 weeks post-intervention3
Clinical pregnancy rate
Compare ongoing clinical pregnancy rates between NMN and placebo groups
Time frame
Up to 12months post-intervention4
Embryo development rate
Analyze and compare the quality of embryos on day 3, 5 or 6 between two groups
Time frame
Up to 8 weeks post-interventionSecondary outcomes
1
Live Birth rates
Compare live Birth rate following the intervention in both groups
Time frame
Up to 24 months post-intervention2
Endocrine hormones including AMH
Changes in endocrine hormones including AMH levels in serum after the interventions.
Time frame
Up to 8 weeks post-intervention3
Average egg retrieval capacity per person
Compare the number of antral follicles in each ovary will be determined using transvaginal ultrasonography in both groups.
Time frame
Up to 8 weeks post-intervention4
Additional in vitro fertilization - outcome indicators
Number of average recruited MII oocytes in both groups
Time frame
Up to 8 weeks post-interventionSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov