This study aims to assess the clinical significance of cleavage stage (Day 3) assisted hatching compared to assisted hatching at the blastocyst stage (Day 5,6,7) of embryo development at the time of trophectoderm (TE) biopsy for patients undergoing in vitro fertilization (IVF) and preimplantation genetic testing for aneuploidy (PGT-A) for treatment of their infertility.
Patients undergoing an IVF cycle with plan for subsequent FET of a single euploid embryo
<4 2PNs prior to randomization
Female partners age <42 years old at start of VOR cycle
AMH ≥ 1.2 ng/mL
All patients who do not voluntarily give their written consent for participation
Patients with a prior failed IVF cycle - defined as no blastocysts
Patients with a history of more than one failed euploid embryo transfer
Donor oocyte cycles
Parallel
Laser Assisted Hatching
Other interventionRoutine assisted hatching procedure will be performed on both groups at the different embryo developmental phases.
Blastulation Rate
Blastulation rate per 2 pronuclei (PN) in each group
Embryo morphologic grade
Gardner and Modified Gardner grading system will be used
Timing of blastulation
proportion of blastocysts that blastulate on day 5,6 or 7
Aneuploidy rate
Rates of whole chromosome positive and negative preimplantation genetic testing (PGT-A) results
Positive pregnancy rate
proportion of positive pregnancy tests per embryo transfer
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