Investigating Periprosthetic Fracture Cultures in Arthroplasty
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Chicago
About this trial
This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment decisions difficult. By studying how often infections are found through lab tests and identifying factors that predict infection, the investigators hope to create better ways to diagnose and care for these patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients (>18 years old) with periprosthetic fractures around primary or revision hip or knee arthroplasty
Patients requiring operative management for these fractures (fixation or revision arthroplasty)
Patients presenting to the University of Chicago Medical Center during two (2) year period (October 2025 to October 2027)
Disqualifiers
Patients undergoing non-operative management for periprosthetic fractures
Any documented or reported history of past prosthetic joint infection of the involved joint
Sinus tract at the time of presentation at the involved joint
Trial population
This population would include all consenting patients older than 18 years who present to the University of Chicago Medical Center with periprosthetic hip or knee fractures and will require operative management of the fracture or infection.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not applicable- observational study
Other interventionThe investigators are only looking to see the rate of positivity of the cultures as well as what the organisms that are found in the cultures are.
Treatment groups
200 Participants
are divided into 1 treatment groupGroup A: Periprosthetic Fractures1 intervention
Trial outcomes
Primary outcomes
1
Culture Positivity Rates
This outcome measure is the percentage of cultures that grow organisms among the population
Time frame
From enrollment to the end of treatment at 14 days.Secondary outcomes
1
Rate of Complications
Number of participants with surgery-related complications within one year after their surgeries.
Time frame
From date of surgery to one year after the specific participant's surgery.2
Culture Organisms
The names, number, and frequency of organisms being found in the cultures.
Time frame
From surgery date to 14 days after surgery.3
Treatments Used
The list of antibiotics used for treating organisms found to be positive in the cultures.
Time frame
From enrollment to one year after surgery.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov