Health TrialsbyHealthPanel

Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement

ConditionsGamma OscillationsHealthy AdultsAlzheimer's Disease (AD)Gamma Entrainment Using Sensory Stimuli (GENUS)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorChang Gung Memorial Hospital

About this trial

This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization. While 40 Hz auditory stimulation has been widely studied, recent evidence suggests optimal frequencies vary by individual. Using a cross-over design with 20 healthy adults, the research compares "optimal" versus "non-optimal" frequencies over one-month intervention periods. Effectiveness is measured through EEG recordings and executive function tasks. The goal is to determine if personalized sensory intervention provides a more effective, non-invasive strategy for enhancing cognitive performance.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age between 18 to 40 years old.

The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education.

Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function.

Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.).

Disqualifiers

Participants enrolled in any cognitive enhancement study within the past two months.

Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.).

Individuals with tinnitus or hyperacusis

Trial design

Design model

Crossover

Treatments tested in this trial

  • Personalized optimal gamma auditory frequency stimulation

    Device

    Participants will receive personalized optimal gamma auditory frequency stimulation using our app downloaded in the mobile device to play the sound for 1 hour per day, 5 days a week, over 1 month.

  • Non-optimal gamma auditory frequency stimulation

    Device

    Participants will receive non-optimal gamma auditory frequency stimulation using our app downloaded in the mobile device to play the sound for 1 hour per day, 5 days a week, over 1 month.

Treatment groups

20 Participants
are divided into 2 treatment groups
Group A: Personalized optimal gamma auditory frequency stimulationExperimental treatment 1 intervention
Group B: Non-optimal gamma auditory frequency stimulationActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

changes in neurophysiological function

EEG oscillation within the gamma band obtained during resting-state and the periods of optimal and non-optimal auditory stimulation will be analyzed to evaluate and compare the neurophysiological changes.

Time frame
Stage 1 baseline (T1), post one-month intervention of stage 1 (T2), stage 2 baseline (T3), post one-month intervention of stage 2 (T4)
2

changes in working memory performance

Behavioral performance and electrophysiological activity will be evaluated via a working memory task.

Time frame
Stage 1 baseline (T1), post one-month intervention of stage 1 (T2), stage 2 baseline (T3), post one-month intervention of stage 2 (T4)
3

changes in inhibitory control performance

Behavioral performance and electrophysiological activity will be evaluated via an inhibitory control task.

Time frame
Stage 1 baseline (T1), post one-month intervention of stage 1 (T2), stage 2 baseline (T3), post one-month intervention of stage 2 (T4)

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Chang Gung Memorial Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: