Retrospective Single-center Analysis of Patients Presenting With Acute Neurological Symptoms, Aiming to Characterize the Frequency, Clinical Features, Diagnostic Pathways, and Healthcare Utilization of Patients with Functional Neurological Diseases
Patients older than 16 years old presenting as an emergency case to the University Hospital Basel between 1 January 2012 and 31 March 2026
with acute neurological symptoms requiring immediate neurological work-up (e.g, acute motor or sensory disturbance, acute speech disorder, acute vestibular disorder, acute cognitive disorder, acute consciousness disorder, acute seizure disorder)
and a documented diagnostic evaluation during hospitalization.
Documented refusal for further use of health related data for research purposes
Insufficient documentation to determine diagnosis or clinical course
Incomplete or inconsistent datasets compromising valid endpoint determination
Younger than 16 years
Patients presenting with acute symptoms
Cohort
Retrospective
collection of patient data
Other interventioncollection of patient data
Frequency of FND
The primary endpoint is the proportion of patients presenting with acute neurological symptoms who receive a diagnosis or likely differential diagnosis of Functional Neurological Disorder (FND) during their index hospital admission.
Secondary Outcomes
Diagnostic Process Measures (%): Referral patterns and evaluation of alternative or concurrent neurological diagnoses.
Secondary Outcomes
Diagnostic Resource Utilization (%): Clinical examination findings, neuroimaging, neurophysiological testing, and laboratory investigations.
Secondary Outcomes
Healthcare Utilization and Outcomes (%): Discharge destination, readmission, outpatient follow-up, and in-hospital mortality.
Secondary Outcomes
Quality of Care Associations (%) Demographic and clinical variables associated with diagnostic performance and healthcare utilization.
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