This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and functional parameters. Approximately 150 patients will be classified into two groups according to their Expanded Disability Status Scale (EDSS) scores: mild disability (EDSS \< 4.0) and moderate disability (EDSS 4.0-6.5). Sarcopenia and dynapenia will be assessed using the ISarcoPRM algorithm. Physical activity, fatigue, and functional independence will also be evaluated.
Aged 18 years or older.
Diagnosed with multiple sclerosis (MS) by a neurologist.
Standardized Mini-Mental State Examination (SMMSE) score ≥24.
Expanded Disability Status Scale (EDSS) score ≤6.5.
Orthopedic surgery within the previous 3 months.
Botulinum toxin injection within the previous 3 months.
Severe cognitive impairment affecting the ability to complete assessments.
Severe cardiopulmonary disease.
Approximately 150 adults diagnosed with multiple sclerosis (MS) receiving care at the Physiotherapy and Rehabilitation Unit of Başkent University Hospital. Participants will be classified into mild (EDSS \<4.0) and moderate (EDSS 4.0-6.5) disability groups.
Cohort
Cross-sectional
Not listed
Prevalence of Sarcopenia
Sarcopenia will be classified using the ISarcoPRM algorithm based on low muscle mass (STAR) combined with reduced handgrip strength and/or physical performance. Prevalence will be calculated as the percentage of participants meeting the criteria in each EDSS group.
Prevalence of Dynapenia
Dynapenia will be defined as reduced muscle strength, independently of muscle mass, based on low handgrip strength (\<32 kg for men; \<19 kg for women) and/or prolonged five-times sit-to-stand time (≥12 seconds). Prevalence will be calculated as the percentage of participants meeting the criteria in each EDSS group.
Handgrip Strength
Handgrip strength will be measured using a calibrated hand dynamometer. The highest value from at least two trials will be recorded in kilograms (kg).
Five-Times Sit-to-Stand Test
Participants will be asked to stand up and sit down five times without using their arms. Completion time will be recorded in seconds. A duration of 12 seconds or longer will indicate reduced physical performance.
Sonographic Thigh Adjustment Ratio (STAR)
Anterior thigh muscle thickness will be assessed using ultrasonography and adjusted for body mass index to calculate STAR. Low muscle mass will be defined as STAR \<1.0 in women and \<1.4 in men.
Sarcopenia Risk (SARC-F)
Sarcopenia risk will be assessed using the five-item SARC-F questionnaire. Total scores range from 0 to 10, with higher scores indicating greater risk. A score of 4 or higher indicates sarcopenia risk.
Click on the lead sponsor to view all of their trials.
Atılım University
Lead sponsor
Baskent University Ankara Hospital
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
