Iodine Uptake After a Low Iodine Diet
ConditionDifferentiated Thyroid Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity Medical Center Groningen
About this trial
The goal of this clinical trial is to compare the difference in thyroid uptake of a low dose radioactive iodine (10 MBq 123-I or 37 MBq 123-I) in athyreotic patients with differentiated thyroid carcinoma before and after a low iodine diet (LID) of 7 days.
The main question it aims to answer is:
• What is the difference in iodine uptake before and after a LID of 7 days?
Uptake of a low dose of 123-iodine will be measured in participants before and after a low iodine diet of 7 days. Researchers will compare the uptake (%) before and after the LID.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients, men and women above the age of 18 years, have to be diagnosed with DTC and have to follow a LID prior to the 131I ablation therapy according to the Dutch DTC guideline
Patients have to be fit to adhere to the study protocol
Patients have to be able to read and understand the Dutch language
Disqualifiers
Age < 18 years
Patients using amiodarone
Patients receiving iodinated contrast < 3 months before the LID
Pregnancy
Trial design
Design model
Single group
Treatments tested in this trial
Low iodine diet
BehavioralBefore ablation and possible subsequent therapy with 131I, patients have to follow a low iodine diet (LID), reducing the iodine intake \< 50 mcg per day and thereby depleting the overall iodine store in the body.
Treatment groups
25 Participants
are divided into 1 treatment groupGroup A: Low iodine dietOther 1 intervention
Trial outcomes
Primary outcomes
1
Iodine uptake
Difference in iodine uptake in percentage
Time frame
7 daysSponsors and contacts
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Source ClinicalTrials.gov