ioMRI in the Surgery of Brain Metastases.

ConditionBrain Metastases

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorTechnical University of Munich

About this trial

The study aims to improve the surgical treatment of brain metastases through the use of advanced imaging techniques. The investigators are examining how intraoperative MRI (iMRI) can aid surgeons in precisely locating and removing tumors, with the potential to enhance surgical outcomes and reduce the need for additional procedures. While iMRI offers the promise of better tumor visualization during surgery, it is also associated with longer surgical times and may carry the risk of increased complications. This study seeks to carefully evaluate these aspects to determine the overall benefits and challenges of iMRI in brain metastasis surgeries. The ultimate aim is to enhance treatment effectiveness and improve recovery and health outcomes for participants dealing with brain metastases.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients for whom surgical resection of brain metastasis is indicated

Disqualifiers

age < 18

3T MRI contraindications

Trial design

Design model

Parallel

Treatments tested in this trial

Surgery with intraoperative MRI
Procedure/Surgery
In this clinical study, we have the unique opportunity to utilize a 3 Tesla MRI intraoperatively during the surgical resection of brain metastases. This approach is distinctly different from standard procedures and offers several advantages. The use of a 3 Tesla MRI provides high-resolution imaging during surgery, offering unparalleled detail of brain structures and tumor boundaries. This level of imaging precision is typically not available in standard surgical procedures. Through real-time visualization, surgeons can better differentiate between tumor tissue and healthy brain tissue, potentially increasing the accuracy of tumor removal and minimizing damage to surrounding areas. Unlike conventional methods, this procedure allows for immediate intraoperative imaging feedback, enabling surgical teams to adjust their techniques dynamically

Treatment groups

154 Participants

are divided into 2 treatment groups

Group A: Surgery without intraoperative MRINo intervention 0 interventions

Group B: Surgery with intraoperative MRIExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Rate for complete resection

The postoperative MRI obtained within 72 hours after surgery will be analyzed to identify the rates of resection.

Time frame

immediately after the surgery

Secondary outcomes

Complications

Hemorrhages, Ischemias, epileptic seizures, hydrocephalus, wound infection, Anesthesiological complications, neurological deficits

Time frame

Perioperatively

Other outcomes

Overall survival

Time frame

Through study completion, an average of 2 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Technical University of Munich

Lead sponsor

Source ClinicalTrials.gov

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