The Investigators will create a clinical database and a Biobank of stem cells derived from the blood of participants with cardiovascular disease. The Investigators will recruit participants from diverse racial and ethnic backgrounds with equal representation from both sexes. The Investigators expect to create stem cells and analyze the blood for protein biomarkers and genetic causes of cardiovascular disease. The stem cell biobank and clinical data will be a powerful tool for studying cardiovascular disease.
Adult (18 to 80 years of age)
Cardiovascular Disease (CVD)
Cerebrovascular Disease (CBD)
Peripheral Vascular Disease (PVD)
Younger than 18 years of age.
Patients not able to provide consent.
We will recruit 200 participants including 150 patients with cardiovascular disease and 50 healthy control participants.
Other
Prospective
Not listed
REDCap Database
Identify patients with cardiovascular disease from ethnically diverse backgrounds and create a clinical database with REDCap.
Induced pluripotent stem cell (iPSC) Biobank
Reprogram peripheral blood mononuclear cells (PBMC) to iPSCs.
Differentiation into Cardiovascular lineages
Differentiate of iPSCs into different cardiovascular lineages (endothelial cells, smooth muscle cells, cardiomyocytes, etc.)
Molecular profiling of participants
Molecular profiling of iPSC-derived tissue and patient serum using microarray, DNA sequencing, and high throughput "omics" technologies (transcriptomic analysis, proteomic analysis, metabolomic studies, and functional assays).
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London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead sponsor
Greenstone Biosciences, Inc.
Collaborator
