Evaluate the proportion of seronegative auto-immune hepatitis and a possible relationship with the severity of the disease. Criteria of severity will be defined by corticodependance, corticoresistance and a severe form of the disease at diagnosis (cirrhosis or fulminant hepatitis). In case of predominant seronegative forms, other auto-antibodies related to this auto-immue hepatitis will be searched.
- Any patient over 18 years old
Patient followed at Hôpital Saint-Antoine or treated for HAI or in Guadeloupe within the framework of the CCRD Filfoie for an acute or chronic AIH under immunosuppressive treatment
Patient affiliate or beneficiary of a social security scheme
Free, informed and written consent signed by the patient and the investigator
Patient under 18 years old
Patient not able to give his/her consent
Viral hepatitis: viruses A to E, Epstein-Barr virus, cytomegalovirus and herpes simplex virus
Isolated primary biliary cholangitis
only acute or chronic AIH patients will be included in the study.
Cohort
Prospective
blood sampling
Other interventionFor the study, a blood sample will be collected from the patient in order to do build up a serological library which will allow the search for rare autoAb whose interest has been demonstrated as prognostic factors of the disease.
histological rereading of seronegative AIH
Percentage comparisons will be made by a chi-2 test or a Fischer test.
assessment of the severity of the disease
\- Number of corticosteroid HAI defined by the maintenance of corticosteroid therapy\> 20mg / d beyond 6 months of treatment - Number of corticosteroid-resistant AIH. Percentage comparisons will be made by a chi-2 test or a Fischer test.
Constitution of a serotheque in order to search for other autoAb described as correlated to the severity of the AIH.
Constitution of a serotheque in order to search for other autoAb described as correlated to the severity of the AIH.
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