Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients

ConditionsHyperuricemia NAFLD (Nonalcoholic Fatty Liver Disease)Liver Fibrosis

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-65

SponsorAssiut University

About this trial

1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients. 2. Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression.

3 - To examine the relationship between serum uric acid levels and liver fibrosis severity\*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD.

4- To identify potential mechanisms underlying the association\*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age: Adults (typically 18-65 years old)

Disqualifiers

excessive alcohol consumption ( > 20 gm /day in men and 10 in g /day in women )

Trial population

Adult obese patients

Trial design

Design model

Other

Time perspective

Cross-sectional

Treatments tested in this trial

*Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .
Diagnostic test
Lab methods
*Imaging Studies:* 1- Ultrasound 2 - FibroScan
Radiation
Imaging
Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.
Device
Instrument

Treatment groups

111 Participants

are divided into 3 treatment groups

Group A: 1- obese +-nafld+- fibrosis3 interventions

Group B: obese +- hyperuricemia +- nfld+- fibrosis3 interventions

Group C: Healthy controls3 interventions

Trial outcomes

Primary outcomes

Prevalence of NAFLD

The proportion of adult obese patients with NAFLD in the study population

Time frame

1 year

Secondary outcomes

Serum uric acid level

The serum uric acid level in adult obese patients

Time frame

1 year

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: