Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorSun Yat-sen University
About this trial
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery
Aged 18 to 80
Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)
Blood routine test: WBC≥3.5×10^9/L, absolute neutrophil count ≥1.5×10^9/L, PLT≥75.0×10^9/L, HGB≥80g/L;
Disqualifiers
The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery
Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes
Estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m²
Horseshoe kidney
Trial design
Design model
Parallel
Treatments tested in this trial
Ischemic preconditioning
Procedure/SurgeryOne day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy
NO ischemic preconditioning
Procedure/SurgeryRoutine partial nephrectomy
Treatment groups
174 Participants
are divided into 2 treatment groupsGroup A: Experimental : Ischemic preconditioningExperimental treatment 1 intervention
Group B: Comparator : No ischemic preconditioningActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
AIRD spectrum score based on the patient's preoperative creatinine level and postoperative peak creatinine level
The AIRD spectrum score was defined as: (observed peak SCr - SCr ideal-peak)/(SCr worstcase-peak - SCr ideal-peak） The range of this indicator should be between 0 and 1, with 0 and 1 representing two extreme situations. 0 indicates that the kidney on the operated side is completely undamaged, while 1 indicates that the kidney on the operated side has completely lost its function.
Time frame
2 weeks after partial nephrectomySecondary outcomes
1
Recovery from ischemia based on the changes in creatinine levels before and after the partial nephrectomy and volume retention rate after the partial nephrectomy
Recovery from ischemia = (%GFR saved)/(%parenchymal mass preserved)
Time frame
3 month after surgerySponsors and contacts
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Source ClinicalTrials.gov
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