IVF Offspring Born in Guangzhou
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 18
SponsorGuangzhou Women and Children's Medical Center
About this trial
The IVF Offspring Born in Guangzhou Cohort Study (IVF-BIG) was established to investigate the short- and long-term effects of exposure in early life on the health of mothers and offspring in Guangzhou, China. Data are collected regarding assisted reproductive technology (ART), environmental, occupational and lifestyle exposures as well as health outcomes in their later life. Biological samples including blood and tissue samples are also collected from participants.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Pregnant women with <20 weeks of gestation
Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
Pregnant women conceived by assited reproductive technology
Disqualifiers
None
Trial population
Mothers conceived by ART in the BIGCS
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Intelligence quotient of offspring
Assessed using Wechsler's Intelligence Scale of Children (WISC) including verbal test and performance test.Intelligence quotient ranges from 40 to 160, in which under 70 is defined as mental retardation
Time frame
At age of 6 years oldSecondary outcomes
1
Prevalence of gestational diabetes, pregnancy induced hypertension, and cesarean section
Assessed by self-reported time of onset and electronic medical records
Time frame
From 20 weeks of gestation to delivery2
Prevalence of stillbirth, preterm birth, small for gestational age, large for gestational age and birth defect
Assesed by electronic records
Time frame
At delivery3
Neurodevelopment at early childhood
Assessed using Gesell Developmental Schedules, including five items of adaptive, gross motor, fine motor, language, and social function
Time frame
At age of 1 year old4
Epegenetic profiles of offspring
Profiling DNA methylation and histone acetylation etc., using blood samples
Time frame
At age of 1 year, 6 years, 12years and 18 years oldSponsors and contacts
Click on the lead sponsor to view all of their trials.
Guangzhou Women and Children's Medical Center
Lead sponsor
University of Birmingham
Collaborator
Source ClinicalTrials.gov