Health TrialsbyHealthPanel

Kawasaki MATCH Trial

ConditionKawasaki Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-17
SponsorUniversity of California, San Diego

About this trial

Evaluating the impact of a machine-learning clinical decision support tool on provider practice when evaluating febrile patients with Kawasaki Disease (KD) and non-KD illnesses.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Measured or subjective fever for >= 3 calendar days

One measured fever >= 38.0 C (home or in ED)

Rash

Conjunctival injection

Disqualifiers

Congenital or Acquired Immune function

Genetic disorders

Current systemic steroid, immunosuppression, or chemotherapy treatment (not including inhaled steroids)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Kawasaki MATCH

    Other intervention

    Providers access the Kawasaki MATCH decision support tool. Patient information is entered into the tool and a risk score is indicated to the provider. Kawasaki MATCH is a previously validated machine-learning decision support tool for the diagnosis of Kawasaki Disease. This tool utilizes patient age, 18 laboratory features, and 5 clinical features to formulate a risk score.

Treatment groups

200 Participants
are divided into 2 treatment groups
Group A: Kawasaki MATCHExperimental treatment 1 intervention
Group B: Routine CareNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Time to Kawasaki Disease treatment (KD patients only)

Time in days from initial ED evaluation to initial IVIG treatment in patients ultimately diagnosed with Kawasaki Disease

Time frame
90 days

Secondary outcomes

1

Kawasaki MATCH score

MATCH score determined by entering patient clinical and laboratory information into the Kawasaki MATCH algorithm. Algorithm output is a decimal between 0 and 1. Scores less than 0.4 will be deemed a prediction of "not Kawasaki Disease" while scores of 0.4 or higher will be deemed "Kawasaki Disease"

Time frame
Day 1 (day of enrollment)
2

Hospital Admission Rate

Proportion of patients admitted to the hospital from the Emergency Department (ED). Admitted patients = 1 Discharged patients = 0

Time frame
Day 1 (day of enrollment)
3

Kawasaki Disease consultation rate

Proportion of patients receiving Kawasaki service consultation

Time frame
Day 1 (day of enrollment)
4

ED return visit

Return to Emergency Department

Time frame
7 days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of California, San Diego

Lead sponsor

Gordon and Marilyn Macklin Foundation

Collaborator

Rady Children's Hospital, San Diego

Collaborator

Source ClinicalTrials.gov
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