Health TrialsbyHealthPanel

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

ConditionsHigh Altitude HypoxiaExercise
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorMcMaster University

About this trial

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

BMI > 30

No prescribed medications (oral contraceptives excluded)

History of smoking

Currently following a ketogenic diet or consuming exogenous ketogenic supplements

Trial design

Design model

Crossover

Treatments tested in this trial

  • Ketone Monoester (KME)

    Dietary supplement

    0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).

  • Placebo

    Dietary supplement

    Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement

Treatment groups

14 Participants
are divided into 2 treatment groups
Group A: High Altitude (3800m; Barcroft Research Station)Experimental treatment 2 interventions
Group B: Low Altitude (334m; University of Guelph)Experimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Cerebral Blood Velocity

Transcranial Doppler ultrasound will be used to measure blood velocity in the middle cerebral artery and posterior cerebral artery. Location of measurements will remain consistent within participants.

Time frame
3 hours

Secondary outcomes

1

Cardiac Output

Cardiac output (L/min) will be measured using a non-invasive cardiac output monitor (Physioflow). The monitor uses signal morphology impedance cardiography to determine cardiac output.

Time frame
3 hours
2

Blood Pressure

Mean arterial pressure (mmHg) will be measured via a brachial cuff placed on the upper arm.

Time frame
3 hours
3

Ventilatory Threshold

Ventilatory threshold (VT) will be calculated based on previously described methods (Gaskill et al., 2001).

Time frame
3 hours
4

End-Tidal Gases

End-tidal oxygen (PETO2) (mmHg) and carbon dioxide (PETCO2) (mmHg) will be collected using a metabolic cart.

Time frame
3 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

McMaster University

Lead sponsor

Source ClinicalTrials.gov
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