Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU admission) in predicting poor and good neurological outcome in comatose patients after cardiac arrest.

Eligibility criteria

Qualifiers

Patients admitted to the ICU for cardiac arrest,

Patients who regained consciousness following in-hospital or out-of-hospital cardiac arrest,

Patients in a coma upon arrival in the ICU, defined by a Glasgow Coma Scale (GCS) score <8,

Patients included in the AfterROSC2 cohort,

Disqualifiers

Terminally ill patients (death expected within 3 hours of admission to the ICU),

Minors,

Patients under legal guardianship,

Pregnant women,

Trial design

Treatments tested in this trial

  • Value of neurofilament light chain (NFL) at different time points

Treatment groups

270 Participants
are divided into 1 treatment group