The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU admission) in predicting poor and good neurological outcome in comatose patients after cardiac arrest.
Patients admitted to the ICU for cardiac arrest,
Patients who regained consciousness following in-hospital or out-of-hospital cardiac arrest,
Patients in a coma upon arrival in the ICU, defined by a Glasgow Coma Scale (GCS) score <8,
Patients included in the AfterROSC2 cohort,
Terminally ill patients (death expected within 3 hours of admission to the ICU),
Minors,
Patients under legal guardianship,
Pregnant women,
Comatose patients after cardiac arrest
Cohort
Prospective
Value of neurofilament light chain (NFL) at different time points
Other interventionValue of neurofilament light chain (NFL) at different time points (H0, H12, H24, H48, H72, H96, and day 7 after ICU admission
modified Rankin Scale (mRS)
Neurological outcome assessed by the modified Rankin Scale (mRS) (An unfavorable outcome is defined as a modified Rankin Scale (mRS) score between 4 and 6 (severe neurological sequelae, persistent coma, or death), and a favorable outcome as a modified Rankin Scale (mRS) score between 0 and 3 (no sequelae, mild to moderate neurological sequelae))
Mortality
Early myoclonus
Clinical, imaging, or neurophysiological neurological abnormalities : early myoclonus (\<72 hours)
Myoclonus status
Clinical, imaging, or neurophysiological neurological abnormalities: myoclonus status (\<72 hours post-CA)
Pupillary and corneal reflexes
Clinical, imaging, or neurophysiological neurological abnormalities: pupillary and corneal reflexes at 72 hours post-CA
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